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AIDS and Related Research (ARRB): Epidemiologic and population studies of infection with HIV and of AIDS with a focus on mechanisms involved in vertical and horizontal transmission, on mathematical models, and on biostatistical tools.
AIDS and Related Research (ARRC): Molecular virology and molecular biology of HIV and the genetics of AIDS
AIDS and Related Research (ARRD): Drug discovery and development as related to the control of viruses causing AIDS and other opportunistic infections causing complications in HIV infected individuals
AIDS and Related Research (ARRE): Clinical manifestations of opportunistic infections involved in AIDS.
AIDS and Related Research (ARRF): Social and behavioral studies of AIDS and of HIV transmission, of risk factors, of prevention intervention, care-giving, social support, and health promotion
AIDS and Related Research (ARRG): Neurobiological study of AIDS and HIV infection, ranging from the neurovirological to the neuropsychological, including all aspects of neuropathogenesis
Chronic Fatigue Syndrome (CFS): All facets of the chronic fatigue syndrome and fibromyalgia
History of Medicine (SSS H): Historical studies of all aspects of medicine, worldwide
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Bio-Psychology (BPO): Brain function and structure; the relationships with behavior, especially ingestion, reproduction and development, learning and memory, emotion, and communication, conditioning and learning; hormones and behavior; comparative studies of behavior
Community Prevention & Control (CPC): Community based studies of health and health-related behavior
Human Development and Aging 1 (HUD-1): Normal infant and child processes and development; normal adolescent and early adult development; cognitive processes and development; social, emotional and personality processes and development
Human Development and Aging 2 (HUD-2): Social, cultural, psychological, and neurological conditions and processes bearing on the health and long-term care of adult and older populations.
Human Development and Aging 3 (HUD-3): Consequences of pregnancy and birth; developmental consequences of neurological diseases, mental retardation, physiological disorders, and specific genetic disorders; problems of infancy; dysfunctional child and adolescent development, learning disabilities, attention deficit disorder
Social Sciences & Population (SSP): Study of human populations and their health phenomena, including sociological, demographic, anthropological, economic, psychological and other social sciences
Medical Biochemistry (MEDB): Molecular basis of metabolic diseases, including inborn errors of metabolism; diagnostic biochemistry; gene therapy approaches to treat metabolic diseases; animal models for studies of inborn errors of metabolism; biochemical and molecular biology approaches to characterizing enzymes, proteins, and receptors and associated signaling pathways; metabolism of lipids, glycolipids, and eiconsanoids in normal and disease states
Pathobiochemistry (PBC): Control of synthesis, breakdown, biochemical structure, and interactions of extracellular matrix components; biochemistry and cellular and molecular biology of cell-matrix and cell-cell interactions in normal and disease states
Physiological Chemistry(PC): Regulation of metabolism with special emphasis on receptors/signal transduction; mechanism and regulation of protein synthesis; DNA/RNA enzymology; transcription regulation; protein and membrane structure; biochemistry of glycoproteins, glycolipids, lipids, and carbohydrates
Biophysical Chemistry (BBCB): Physical chemistry and structure of proteins, lipids, and other biopolymers and membranes, including studies of the biological, chemical, and physical properties; structure determination techniques include X-ray crystallography, NMR, ESR, and spectroscopy
Medicinal Chemistry (MCHA): Synthetic organic, medicinal, physical organic and organometallic chemistry; reactions and biochemical, biological, pharmacological or chemotherapeutic activity of low molecular weight compounds of natural or synthetic origin
Metallobiochemistry (BMT): Analytical chemistry; clinical chemistry; metallobiochemistry, including organometallic, organometalloid, metalloprotein, metalloenzyme, synthetic inorganic, and coordination chemistry
Molecular and Cellular Biophysics (BBCA): Structure/function relationships of biological macromolecules by methodologies such as NMR, X-ray crystallography, spectroscopy, modeling, and computational/thermodynamic/kinetic analysis
Physical Biochemistry (PB): chemical reactions in biological systems, including biochemical energetics, enzymology, and the structure-function relationships of biomolecules
Cardiovascular and Renal (CVB): Basic and clinical aspects of cardiovascular function in normal and disease states; renal hemodynamics and function as related to hypertension, including endogenous vasoactive substances and their mechanism of action
Experimental Cardiovascular Sciences (ECS): Basic and clinical aspects of the circulation and blood vessel responsiveness in normal and disease states (e.g. hypertension) and their neural control
Hematology (HEM 1): General hematology; metabolism of red and white cells; blood formation, including hematopoietic stem and progenitor cells in differentiation and bone marrow transplantation; hemostasis, including coagulation and fibrinolysis; anemia, leukema and related disorders
Hematology 2 (HEM-2): Transfusion medicine and blood groups; general hematology; metabolism of red and white cells; blood formation, including hematopoietic stem and progenitor cells in differentiation and bone marrow transplantation; hemostasis, including coagulation and fibrinolysis; anemia, leukema and related disorders
Pathology A (PTHA): Pathology of the vascular and renal systems; pathogenesis of atherosclerosis; cell biology of vascular endothelium and smooth muscle; angiogenesis; immunological aspects of injury and inflammation in the cardiovascular and renal systems; renal mesangial cell biology; basement membrane pathology of the vascular and renal systems Note: Pathology A does not review studies of tumor biology
Pharmacology (PHRA): Pharmacology, especially cardiovascular, receptor/ion channel/signal transduction interactions; drug formulation, delivery and metabolism; pharmacokinetics/pharmacodynamics; clinical pharmacology
Cellular Biology and Physiology Study Section-1 (CBY-1): Genesis, structure, and function of cells and cell organelles with emphasis on all aspects of cell motility, intracellular compartmentation and targeting to the various membrane compartments (endocytosis, exocytosis, secretion); cell-cell and cell-substrate interactions, e.g., gap junction structure and function and matrix-receptor interactions; developmental biology including embryogenesis, induction, pattern formation, and differentiation of cells and tissues
Cellular Biology and Physiology Study Section (CBY-2): Intracellular and intercellular signal transduction; regulation of the cell cycle; growth factor, oncogene and tumor suppressor function in mitogenesis, transformation, and apoptosis; structure and function of membrane transport processes.
Human Embryology and Developmental Study Section (HED-2): All aspects of embryogenesis and development; regulation of the cell cycle; early stages of tumorigenesis; apoptosis/programmed cell death; cell senescence
International and Cooperative Projects Study Section (ICP): International awards supported or processed through the Fogarty International Center and for other special programs supported by the various Institutes
Molecular Biology Study Section(MBY): Mechanistic aspects of eukaryotic transcription (including RNA processing and stability), replication, and translation
Molecular Cytology Study Section (CTY): Genesis, structure, function and senescence of cells and cell organelles with emphasis on nuclear components and activities (such as replication, transcription, and RNA processing and transport), cell motility (particularly of muscle) and intracellular compartmentation and targeting to the various membrane compartments (endocytosis, exocytosis, secretion); muscle cell biology and myogenesis
Endocrinology (END): Physiological, pathophysiological, and molecular processes involving hypothalamic, pituitary, pineal, thyroid, adrenal, and pancreatic hormones
Human Embryology 1 (HED-1): Mammalian embryology and development with emphasis on mid- to late-pregnancy, parturition, and neonatal development; maternal/fetal physiology
Reproductive Biology (REB): Reproduction from the early stages of the developing gonad up to and through implantation of the embryo
Reproductive Endocrinology (REN): Basic and clinical reproductive endocrinology; diseases, including cancer, of the reproductive accessory organs
Genetics (GEN): Genetics of all biological systems except mammals, including, but not limited to, insects, fish, fungi, worms, protozoa, and plants; genetic concepts and procedures such as gene expression and regulation, development, genetic recombination, DNA repair, meiosis, population genetics, and evolution
Genome (GNM): Technology development in molecular biology, genetics, and genomics; generation of mapping and DNA sequencing data in all organisms; informatics studies for analysis of maps and DNA sequences; tools and resources for storage and dissemination of data; quantitative genetics; analysis of DNA polymorphisms; genetic and physical mapping techniques; gene identification methods; DNA vectors; DNA chip technology; development of new molecular, chemical and physical methods for DNA sequencing; algorithms for sequence analysis and assembly; base calling software; databases
Mammalian Genetic (MGN): Genetic studies in mammals; mapping and cloning of normal and disease genes; analysis of gene function; genetic epidemiology; population genetics; mitochondrial genetics; immunogenetics; molecular evolution; cancer genetics; cytogenetics
Ethical, Legal and Social Implications of Human Genetics Special Emphasis Panel: psychosocial issues for both consumers and professionals in testing for genetic diseases including cancer; sociological/anthropological studies related to human genetics; medical ethics/theological ethics/empirical ethics studies related to human genetics; philosophical studies; genetics policy studies; legal studies of issues in human genetics; history of science studies
Health Promotion and Disease Prevention IRG
Dr. Paul Strudler, IRG Chief
Epidemiology, prevention and control of human disease: nursing research relevant to clinical care of patients and families; studies characterizing the effects of xenobiotics and toxic agents
Alcohol and Toxicology (ALTX-2): Toxicant and alcohol action at the cellular or genetic level related to carcinogenesis, teratogenesis, maternal systems-dependent developmental abnormalities, immunotoxicology, genotoxicology, and biomarkers
Alcohol and Toxicology (ALTX-3): Effects of toxicants and alcohol on the central nervous system, including behavior, neuropathology, neurophysiology, neuropharmacology, neuroendocrinology, neuroimmunology, and neuroteratology
Alcohol and Toxicology (ALTX-4): Molecular, cellular, physiologic, and pharmacologic mechanisms of toxicant and alcohol action on the bone, cardiovascular, gastrointestinal, hepatic, renal, pulmonary, endocrine/exocrine, cardiac, and skeletal muscle systems.
Epidemiology and Disease Control 1 (EDC-1): Description, detection, etiology, prevention, treatment, and control of chronic and communicable diseases in the community, especially cardiovascular disease, diabetes, digestive and kidney diseases, arthritic and rheumatoid diseases, musculoskeletal diseases, osteoporosis, menopause, pregnancy and fertility, child growth and development, and new epidemiologic methods
Epidemiology and Disease Control 2 (EDC-2): Description, detection, etiology, prevention, treatment, and control of chronic and communicable diseases in the community, especially cancer, infectious diseases, environmental and occupational risk factors, pulmonary diseases, sleep disorders, and neurological disorders, including Alzheimer's disease, dementias, stroke, and epilepsy
Nursing (NURS): Basic and applied studies of responses to actual or potential health problems, especially symptom management in acute or chronic illness, approaches to promoting health and preventing disease, and interventions influencing patient health outcomes and reducing costs; nursing systems; ethics
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Experimental Immunology (EI): Cellular and molecular aspects of the function of the immune system, particularly relating to immunity against cancer; immunodiagnosis; gene therapy of tumors; cellular and molecular aspects of cytokine therapy of tumors
Immunobiology (IMB): Functional and mechanistic aspects of basic immunology; cellular and molecular immunology; immunogenetics; immunoregulation; development of T and B cells; T and B cell activation; tissue and organ transplantation; immunology of aging; tumor immunology
Immunological Sciences (IMS): Function of the immune system in relation to the development of immunological diseases, such as clinical allergy and autoimmune diseases; immune cell regulation in the context of disease; animal models of autoimmune diseases; hypersensitivity; developmental aspects of the immune response
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Bacteriology and Mycology 2 (BM-2): Host-parasite relationships; pathogenesis; etiology; diagnostic procedures and vaccine preparation; environmental conditions in relation to bacterial and fungal agents and the host; food microbiology; basic biology of disease agents
Experimental Virology (EVR): Basic molecular virology, morphology, host/virus interactions; viral immunity and pathogenesis; vaccine development and antiviral agents; plant viruses
Microbial Physiology and Genetics 1 (MBC-1): Metabolism; structure, and morphogenesis of microorganisms, excluding protozoa
Microbial Physiology and Genetics 2 (MBC-2): Genetics and molecular biology of bacteria, bacteriophage, Cyanobacteria, and Archaea
Tropical Medicine and Parasitology (TMP): Experimental, survey, and clinical projects designed to study and control parasites, pests, vectors, and poisonous animals that carry or cause disease in humans and other animals
Virology (VR): Basic molecular virology, morphology, host/virus interactions; viral immunity and pathogenesis; vaccine development and antiviral agents; plant viruses
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General Medicine B (GMB): Basic and clinical studies of renal consequences of diabetes, hypertension, ischemia, and other diseases; water and electrolyte balance; mineral metabolism; bone and kidney function
Geriatrics & Rehabilitation Medicine (GRM): geriatrics, clinical gerontology and rehabilitation medicine
Oral Biology and Medicine 1 (OBM-1): clinical dental science and oral biology; chemistry and biochemistry of salivary components; dental materials; oral microbiology and immunology; oral pathology; cell and molecular biology of salivary tissues
Oral Biology and Medicine 2 (OBM-2): clinical dental sciences and oral biology; craniofacial developmental biology; cell biology of mineralized tissues; biochemistry and physical chemistry of mineralization; oral microbiology and immunology; dental materials; oral surgery and implants; muscle and joint pathology and pain
Orthopedics and Musculoskeletal (ORTH): the entire musculoskeletal system in terms of physiological and bioengineering principles; most aspects of clinical orthopedic research
Urological Research Special Emphasis Panel (UROL): Basic and clinical studies of the urinary and urogenital tracts, including genetics, embryology, development, function, and pathophysiology of the ureter, bladder (including smooth muscle function), prostate, urethra, penis, vas deferens, epididymis and testis; specific conditions include benign prostatic hyperplasia, cryptorchism, hydronephrosis, hypospadias, impotence, urinary incontinence and voiding dysfunction, infection, interstitial cystitis, infertility, neurogenic bladder, urogenital anatomic support, testicular torsion, obstructive uropathy, prostatitis, testicular descent, urolithiasis, and nephrolithiasis Note: Topics in oncology are not included.
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Neurology B-1 (NEUB-1): Basic studies with an emphasis on neurophysiology of synapses and cell biology of neurons and glia; studies of axonal transport; clinical studies involving motor control; neuropathological studies of ischemia
Neurology B-2 (NEUB-2): Brain development, regeneration, and transplantation; cell and molecular studies of tropic and trophic factors
Neurology C (NEUC): Molecular and biochemical neuroscience; gene structure; gene regulation; gene activity in the developing nervous system; pathfinding; extracellular matrix; molecular studies of learning and memory
Neurological Sciences 1 (NLS-1): Fundamental neuroscience with an emphasis on neurotransmitter receptors, transporters, signal transduction; cytoskeleton; biochemistry and cell biology of neurodegenerative disease
Neurological Sciences 2 (NLS-2): Studies of the central and peripheral nervous systems primarily in the fields of neurotransmitter receptor biochemistry and function, pain mechanisms, and neurotransmitter function
Neurological Sciences 3 (NLS-3): Neuropathology; neuroimmunology; gene therapy for central nervous system disorders; clinical and basic studies of the blood brain barrier; cerebral blood flow; neurodegenerative disease; regeneration; inflammation of the central nervous system; trauma and spinal cord injury; neuron and glial cell biology
NOTE: The NIH is currently reorganizing the review of grant applications in the neurosciences and integrating some review activities that were formerly in the National Institute of Drug Abuse and National Institute of Mental Health. Changes will be made in this IRG as a result of that activity.
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Metabolism (MET): Physicochemical processes of metabolism of carbohydrates, amino acids, proteins, and lipids in normal and disease states
Nutrition (NTN): Applied, experimental, and clinical nutrition of humans and animals in vivo and in vitro
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Experimental Therapeutics 1 (ET-1): Evaluation of experimental (pre-clinical) therapy of neoplasia; basic mechanisms of action of cancer therapeutic agents in in vitro and in vivo model systems
Experimental Therapeutics 2 (ET-2): Evaluation of experimental therapy (preclinical and clinical) of neoplastic diseases, especially the translation of basic studies to clinical applications
Metabolic Pathology (MEP): Effects of nutritional deficiencies/excesses in cellular pathology; studies of immunological and molecular aspects of carcinogenesis and chemoprevention
Pathology B (PTHB): Laboratory and clinical investigations of cancer, including tumor markers, oncogenes, the pathogenesis of cancer invasion and metastasis, cytogenetics and tissue culture studies on tumors; morphologic changes in normal and tumor cells
Radiation (RAD): Interaction of radiation (and heat) with biological material at the molecular, cellular, and in vivo level; clinical therapeutic uses of such radiation
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Physiology (PHY): Fundamental physiological principles, studied at the cellular or subcellular level, that primarily emphasize aspects of membrane processes, bioexcitability, and contractility in cells from a variety of organs
Respiratory & Applied Physiology (RAP): Basic and clinical research related to certain aspects of the respiratory system (e.g. control of breathing, gas exchange, lung mechanics, and respiratory muscles) and of exercise physiology (e.g. muscle plasticity, muscle glucose metabolism, cardiovascular adaptations, and thermoregulation)
Sensory Disorders and Language (CMS): Basic, applied, and clinical research on the neural, laryngeal, and orofacial mechanisms involved in speech production, speech and language development, and speech disorders; structure, biochemistry, pharmacology, and physiology of sensory systems concerned with olfactory, gustatory, tactile, and somatosensory sensation
Visual Sciences A (VISA): Basic, applied, and clinical research on the anterior portion of the eye (cornea, lens, ciliary body, lacrimal gland) and its disorders, including glaucoma, cataracts, congenital and developmental abnormalities, inflammatory and infectious diseases; heredofamilial and degenerative diseases, and ocular manifestations of systemic diseases, tumors, injury, and trauma
Visual Sciences B (VISB): Basic, applied, and clinical research on the visual pathways of the brain, eye, and extraocular muscle system that function in visual sensation and related eye movements in both normal vision and visual or visual-motor deficits, low vision, blindness, myopia, amblyopia, strabismus, neuro-ophthalmic and extraocular (muscular, orbital) disorders
Visual Sciences C (VISC): Basic, applied, and clinical research on the posterior portion of the eye (retina, retinal pigmented epithelium, choroid, retinal vasculature) and related disorders, including degenerative and vascular diseases and the retinal involvement in diabetes and glaucoma
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Diagnostic Radiology (RNM): Basic and clinical studies of diagnostic imaging and spectroscopy of the body to obtain anatomical or physiologic information pertinent to the diagnosis of disease
Surgery, Anesthesiology, and Trauma (SAT): Experimental and clinical anesthesiology; experimental and clinical surgery, principally related to organ transplantation and to burns, trauma, shock, sepsis, and ischemia
Surgery and Bioengineering (SB): Basic and clinical investigations of surgical problems of the cardiac, vascular, pulmonary, and gastrointestinal systems; bioengineering ; biomaterials and grafting/reconstruction
Statistics (STA): Development of statistical models to analyze biomedical and epidemiological data
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