The AMP-activated Protein Kinase (AMPK/SNF1) Project

AMP-activated protein kinase (AMPK) is a master metabolic regulator. AMPK activation leads to the down regulation of energy-demanding, anabolic processes (fatty acid and cholesterol biosynthesis, gluconeogenesis, glycogen synthesis and others) and the stimulation of energy-producing, catabolic processes (fatty acid oxidation, glucose uptake, glycolysis and others). AMPK is a dual inhibitor of ACC1 and ACC2, by phosphorylating them near the N terminus.

AMPKs are hetero-trimeric enzymes, with a catalytic alpha subunit and two regulatory (beta and gamma) subunits. The alpha subunit contains the protein kinase domain, and the beta subunit a glycogen binding domain. The gamma subunit contains 4 repeats of the cystathionine-beta-synthase (CBS) motif. Each CBS tandem pair is also known as the Bateman domain. AMP is believed to regulate AMPK by binding to the gamma subunit.

AMPK is an attractive target for drug discovery. Metformin is believed to function through indirect activation of this kinase.

Major findings from this project

Publications from this project

Funding for this project

© copyright 2006-2017, Liang Tong.