The BEACH Domain Project

BEACH domains are highly conserved in a large family of eukaryotic proteins that are involved in vesicle trafficking, membrane dynamics, cytokinesis, and receptor signaling.

The BEACH domain was first identified in the proteins beige and CHS. Chediak-Higashi Syndrome (CHS) is a rare, autosomal recessive disorder that can cause severe immunodeficiency and albinism in humans. Unless treated by bone marrow transplantation, CHS patients generally die in childhood. beige is the name for CHS disease in mice and other animals.

BEACH domains share no detectable sequence homology with other proteins in the database. Its exact biochemical/biological function is currently not known. BEACH-containing proteins are generally very large, from 900 residues for the protein FAN to 3800 residues for CHS.

Major findings from this project

Publications from this project

Funding for this project

© copyright 2003-2017, Liang Tong.