The Cyclic di-AMP Signaling Project

Updated Jan. 2023

Cyclic di-AMP (c-di-AMP, cdA) was first discovered in 2008, and this second messenger has crucial roles in many bacterial processes, including central metabolism, cell wall metabolism, DNA repair, potassium homeostasis, osmotic regulation, sporulation, stress response, antibiotic resistance, biofilm formation and virulence. It is essential in many bacteria, and riboswitches and proteins have been identified as its sensors. It also has an important role in host-pathogen interactions.

Using a chemical proteomics approach, a set of proteins that interact with c-di-AMP was identified in Listeria monocytogenes. The biochemical and physiological effects of c-di-AMP binding to these target proteins were then characterized. The molecular basis for the binding was also determined.

Major findings from this project

Publications from this project

Funding for this project

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