The HCMV Protease Project

Human cytomegalovirus (HCMV), a herpesvirus, infects most of the population and can cause severe health problems in immuno-suppressed and immuno-comprised individuals. HCMV protease is required for the life cycle of the virus, and is therefore a promising target for the development of novel anti-herpes agents.

The protease is a serine protease, but shares no sequence homology to other serine proteases (chymotrypsin, subtilisin for example). In fact, no cellular homologs of this viral protease have been identified so far, even with the knowledge of the complete genome sequences of various organisms.

Major findings from this project

Publications from this project

Funding for this project

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