The TIR Domain Signal Transduction Project

Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) play crucial in many host immune responses. Signal transduction through these receptors ultimately leads to the activation of the NF-kB and AP-1 transcription factors.

The Toll/Interleukin-1 receptor (TIR) domain is the conserved intracellular domain of the two families of receptors. This domain is also shared by the downstream adapter molecule MyD88. Upon receptor activation, it is believed that a TIR domain signaling complex is formed between the receptor and the adapter TIR domains. A single point mutation in the TIR domain of murine TLR4 (the Lps_d mutation) renders the mice hyporesponsive to lipopolysaccharide (LPS).

Major findings from this project

Publications from this project

Funding for this project

© copyright 2000-2017, Liang Tong.