Liang Tong Lab at Columbia University

The Malic Enzyme (ME) Project


Malic enzymes catalyze the oxidative decarboxylation of malate to pyruvate and CO2, with the concomitant reduction of the cofactor NAD(P)+ to NAD(P)H. A divalent cation is required for this catalysis.

Malic enzymes have been found in most living organisms, from E. coli to man. The amino acid sequences of malic enzymes are highly conserved, but they share little sequence homology to other proteins.

Major findings from this project

Publications from this project

Funding for this project


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