Liang Tong Lab at Columbia University

Google Scholar Site for Liang Tong

PUBLICATIONS (316 total, 268 research papers + 48 reviews/book chapters): Updated Jan. 2023

Peer-reviewed publications

1.      X.-L. Jin, K.-L. Tang, L. Tong & Y.-Q. Tang. (1984). The reactions of ammonium thiomolybdate with amino-acid salts of copper(II) and the crystal structure of the product Cu2MoS4(py)4. Nature journal (China), 7, 314-316.

2.      X.-L. Jin, K.-L. Tang, L. Tong & Y.-Q. Tang. (1986). The reaction between (NH4)2MoS4 and the cupric salts of amino acids and the crystal structure of the reaction product Cu2MoS4(py)4. Scientia Sinica (Chinese Edition), B11, 1136-1142.

3.      A.M. de Vos, L. Tong, M.V. Milburn, P.M. Matias, J. Jancarik, S. Noguchi, S. Nishimura, K. Miura, E. Ohtsuka & S.-H. Kim. (1988). Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21. Science, 239, 888-893.

4.      R.M. Glaeser, L. Tong & S.-H. Kim. (1989). Three-dimensional reconstructions from incomplete data: Interpretability of density maps at "atomic" resolution.Ultramicroscopy, 27, 307-318.

5.      L. Tong, M.V. Milburn, A.M. de Vos & S.-H. Kim. (1989). Structure of ras protein. Science, 245, 244-244.

6.      M.V. Milburn, L. Tong, A.M. de Vos, A. Brunger, Z. Yamaizumi, S. Nishimura & S.-H. Kim. (1990). Molecular switch for signal transduction: Structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247, 939-945.

7.      A.T. Brunger, M.V. Milburn, L. Tong, A.M. de Vos, J. Jancarik, Z. Yamaizumi, S. Nishimura, E. Ohtsuka & S.-H. Kim. (1990). Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain. Proc. Natl. Acad. Sci. U.S.A. 87, 4849-4853.

8.      L. Tong & M.G. Rossmann. (1990). The locked rotation function. Acta Cryst. A46, 783-792.

9.      L. Tong, A.M. de Vos, M.V. Milburn & S.-H. Kim. (1991). Crystal structures at 2.2A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. J. Mol. Biol. 217, 503-516.

10.    H.-K. Choi,* L. Tong,* W. Minor, P. Dumas, U. Boege, M.G. Rossmann & G. Wengler. (1991). Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion. Nature, 354, 37-43. (*–equal first authors; News and Views feature on p. 22-23)

11.    M.G. Rossmann, R. McKenna, L. Tong, D. Xia, J.-B. Dai, H. Wu, H.-K. Choi & R.E. Lynch. (1992). Molecular replacement real space averaging. J. Appl. Cryst. 25, 166-180.

12.    G.G. Prive, M.V. Milburn, L. Tong, A.M. de Vos, Z. Yamaizumi, S. Nishimura & S.-H. Kim. (1992). X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis. Proc. Natl. Acad. Sci. U.S.A. 89, 3649-3653.

13.    L. Tong, H.-K. Choi, W. Minor & M.G. Rossmann. (1992). Structure determination of Sindbis virus core protein using isomorphous replacement and molecular replacement averaging between two crystal forms. Acta Cryst. A48, 430-442.

14.    L. Tong, G. Wengler & M.G. Rossmann. (1993). Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures. J. Mol. Biol. 230, 228-247.

15.    L. Tong & M.G. Rossmann. (1993). Patterson-map interpretation with noncrystallographic symmetry. J. Appl. Cryst. 26, 15-21.

16.    L. Tong, M. Cardozo, P.-J. Jones & J. Adams. (1993). Preliminary structural analysis of the mutations selected by non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. & Med. Chem. Lett. 3, 721-726.

17.    L. Tong, S. Pav, C. Pargellis, F. Do, D. Lamarre & P.C. Anderson. (1993). Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures. Proc. Natl. Acad. Sci. U.S.A. 90, 8387-8391. (Corresponding author)

18.    K. Pal, M.L. Behnke & L. Tong. (1993). A general stereocontrolled synthesis of cis-2,3 disubstituted pyrrolidines and piperidines. Tetrahedron Lett. 34, 6205-6208.

19.    L. Tong. (1993). REPLACE, a suite of computer programs for molecular-replacement calculations. J. Appl. Cryst. 26, 748-751.

20.    J.R. Somoza, F. Jiang, L. Tong, C.-H. Kang, J.M. Cho & S.-H. Kim. (1993). Two crystal structures of a potently sweet protein. Natural monellin at 2.75A resolution and single-chain monellin at 1.7A resolution. J. Mol. Biol. 234, 390-404.

21.    S. Pav, K. Lubbe, F. Do, D. Lamarre, C. Pargellis & L. Tong. (1994). Microtube batch protein crystallization: Applications to human immunodeficiency virus type 2 (HIV-2) protease and human renin. Proteins: Structure, Function, and Genetics, 20, 98-102.

22.    R.J. Snow, W.W. Bachovchin, R.W. Barton, S.J. Campbell, S.J. Coutts, D.M. Freeman, W.G. Gutheil, T.A. Kelly, C.A. Kennedy, D.A. Krolikowski, S.F. Leonard, C.A. Pargellis, L. Tong & J. Adams. (1994). Studies on proline boronic acid dipeptide inhibitors of dipeptidyl peptidase IV: Identification of a cyclic species containing a B-N bond. J. Amer. Chem. Soc. 116, 10860-10869.

23.    L. Tong, S. Pav, S. Mui, D. Lamarre, C. Yoakim, P. Beaulieu & P.C. Anderson. (1995). Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere. Structure, 3, 33-40. (Corresponding author)

24.    L. Tong, S. Pav, D. Lamarre, L. Pilote, S. LaPlante, P.C. Anderson & G. Jung. (1995). High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors. J. Mol. Biol. 250, 211-222. (Corresponding author)

25.    L. Tong & M.G. Rossmann. (1995). Reciprocal space molecular replacement averaging. Acta Cryst. D51, 347-353.

26.    M.A. Cornea-Hasegan, Z. Zhang, R.E. Lynch, D.C. Marinescu, A. Hadfield, J.K. Muckelbauer, S. Munshi, L. Tong & M.G. Rossmann. (1995). Phase refinement and extension by means of non-crystallographic symmetry averaging using parallel computers. Acta Cryst. D51, 749-759.

27.    J.R. Proudfoot, K.D. Hargrave, S. Kapadia, U.R. Patel, K.G. Grozinger, D.W. McNeil, E. Cullen, M. Cardozo, L. Tong, T.A. Kelly, J. Rose, E. David, S.C. Mauldin, V.U. Fuchs, J. Vitous, M. Hoermann, J.M. Klunder, P. Raghavan, J.W. Skiles, P. Mui, D.D. Richman, J.L. Sullivan, C.-K. Shih, P.M. Grob & J. Adams. (1995). Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-Substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes. J. Med. Chem. 38, 4830-4838.

28.    L. Tong, S. Pav, D. Lamarre, B. Simoneau, P. Lavallee & G. Jung. (1995). Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors. J. Biol. Chem. 270, 29520-29524. (Corresponding author)

29.    J.K. Muckelbauer, M. Kremer, I. Minor, L. Tong, A. Zlotnick, J.E. Johnson & M.G. Rossmann. (1995). The structure determination of Coxsackievirus B3 to 3.5A resolution. Acta Cryst. D51, 871-887.

30.    S.J. Harrop, J.R. Helliwell, T.C.M. Wan, A.J. Kalb (Gilboa), L. Tong & J. Yariv. (1996). Structure solution of a cubic crystal of Concanavalin A complexed with methyl a-D-glucopyranoside. Acta Cryst. D52, 143-155.

31.    L. Tong, T.C. Warren, J. King, R. Betageri, J. Rose & S. Jakes. (1996). Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0A and 1.8A resolution. J. Mol. Biol. 256, 601-610. (Corresponding author)

32.    L. Tong. (1996). The locked translation function and other applications of a Patterson correlation function. Acta Cryst. A52, 476-479.

33.    G.P. Roth, S.F. Leonard & L. Tong. (1996). Complementary selectivity in the alkylation of chiral bicyclic lactam enolates. J. Org. Chem. 61, 5710-5711.

34.    L. Tong, C. Qian, M.-J. Massariol, P.R. Bonneau, M.G. Cordingley & L. Lagace. (1996). A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease. Nature, 383, 272-275. (Corresponding author)

35.    L. Tong. (1996). Combined molecular replacement. Acta Cryst. A52, 782-784.

36.    C. Momany, L.C. Kovari, A.J. Prongay, W. Keller, R.K. Gitti, B.M. Lee, A.E. Gorbalenya, L. Tong, J. McClure, L.S. Ehrlich, M.F. Summers, C. Carter & M. G. Rossmann. (1996). Crystal structure of dimeric HIV-1 capsid protein. Nature Struct. Biol. 3, 763-770.

37.    S.R. LaPlante, L. Tong, N. Aubry, S. Pav, G. Jung & P.C. Anderson. (1996). Several polyhydroxymonoamide renin inhibitors assume similar conformations in the unbound and renin-bound states. Int. J. Pept. Protein Res. 48, 401-410.

38.    S. Pav, D.M. White, S. Rogers, K.M. Crane, C.L. Cywin, W. Davidson, J. Hopkins, M.L. Brown, C.A. Pargellis & L. Tong. (1997). Crystallization and preliminary crystallographic analysis of recombinant human p38 MAP kinase. Protein Science, 6, 242-245.

39.    G.P. Roth, M. Emmanuel & L. Tong. (1997). Resolution and assignment of the absolute stereochemistry of a trans-2,3-diarylpyrrolidine LTB4 inhibitor intermediate. Tetrahedron:Asymmetry, 8, 185-186.

40.    L. Tong, S. Pav, D.M. White, S. Rogers, K.M. Crane, C.L. Cywin, M.L. Brown & C.A. Pargellis. (1997). A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nature Struct. Biol. 4, 311-316. (Corresponding author)

41.    P.L. Beaulieu, D. Wernic, A. Abraham, P.C. Anderson, T. Bogri, Y. Bousquet, G. Croteau, I. Guse, D. Lamarre, F. Liard, W. Paris, D. Thibeault, S. Pav & L. Tong. (1997). Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere. J. Med. Chem. 40, 2164-2176.

42.    L. Tong, C. Qian, W. Davidson, M.-J. Massariol, P.R. Bonneau, M.G. Cordingley & L. Lagace. (1997). Experiences from the structure determination of human cytomegalovirus protease. Acta Cryst. D53, 682-690. (Corresponding author)

43.    L. Tong, T.C. Warren, S. Lukas, J. Schembri-King, R. Betageri, J.R. Proudfoot & S. Jakes. (1998). Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding. J. Biol. Chem. 273, 20238-20242. (Corresponding author)

44.    L. Tong, C. Qian, M.-J. Massariol, R. Deziel, C. Yoakim & L. Lagace. (1998). Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease. Nature Struct. Biol. 5, 819-826. (Corresponding author)

45.    Y.C. Park, V. Burkitt, A.R. Villa, L. Tong & H. Wu. (1999). Structural basis for self-association and receptor recognition of human TRAF-2. Nature, 398, 533-538.

46.    S.R. LaPlante, P.R. Bonneau, N. Aubry, D.R. Cameron, R. Deziel, C. Grand-Maitre, C. Plouffe, L. Tong & S. H. Kawai (1999). Characterization of the human cytomegalovirus protease as an induced-fit protease and the implications to the design of mechanism-based peptidyl inhibitors. J. Amer. Chem. Soc. 121, 2974-2986.

47.    P.L. Beaulieu, D.R. Cameron, J.-M. Ferland, J. Gauthier, E. Ghiro, J. Gillard, V. Gorys, M. Poirier, J. Rancourt, D. Wernic, M. Llinas-Brunet, R. Betageri, M. Cardozo, E.R. Hickey, R. Ingraham, S. Jakes, A. Kabcenell, T. Kirrane, S. Lukas, U. Patel, J. Proudfoot, R. Sharma, L. Tong & N. Moss. (1999). Ligands for the tyrosine kinase p56lck SH2 domain:  Discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements. J. Med. Chem. 42, 1757-1766.

48.    G. Bhargava, S. Mui, S. Pav, H. Wu, G. Loeber & L. Tong. (1999). Preliminary crystallographic studies of human mitochondrial NAD(P)+-dependent malic enzyme. J. Struct. Biol. 127, 72-75.

49.    Y. Xu, G. Bhargava, S. Mui, S. Pav, G. Loeber, H. Wu & L. Tong. (1999). Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases. Structure, 7, 877-889.

50.    C. Qian, L. Lagace, M.-J. Massariol, C. Chabot, C. Yoakim, R. Deziel & L. Tong. (2000). A rational approach towards successful crystallization and crystal treatment of human cytomegalovirus protease and its inhibitor complex. Acta Cryst. D56, 175-180.

51.    Z. Yang, D.L. Floyd, G. Loeber & L. Tong. (2000). Structure of closed form of malic enzyme and implications for catalytic mechanism. Nature Struct. Biol. 7, 251-257.

52.    W.-Y. Chou, H.-P. Chang, C.-H. Huang, C.-C. Kuo, L. Tong & G.-G. Chang. (2000). Characterization of the functional role of Asp141, Asp194, and Asp464 residues in the Mn2+-L-malate binding of pigeon liver malic enzyme. Protein Sci. 9, 242-251.

53.    P. L. Beaulieu, P. C. Anderson, D. R. Cameron, G. Croteau, V. Gorys, C. Grand-Maitre, D. Lamarre, F. Liard, W. Paris, L. Plamondon, F. Soucy, D. Thibeault, D. Wernic, C. Yoakim, S. Pav & L. Tong. (2000). 2',6'-dimethylphenoxyacetyl: a new achiral high affinity P3-P2 ligand for hydroxyethylamine-based HIV protease inhibitors. J. Med. Chem. 43, 1094-1108.

54.    Z. Yang, R. Batra, D.L. Floyd, H.-C. Hung, G.-G. Chang & L. Tong. (2000). Potent and competitive inhibition of malic enzymes by lanthanide ions. Biochem. Biophys. Res. Commun. 274, 440-444.

55.    Y. Xu, X. Tao, B. Shen, T. Horng, R. Medzhitov, J.L. Manley & L. Tong. (2000). Structural basis for signal transduction by the Toll/Interleukin-1 receptor (TIR) domains. Nature, 408, 111-115.

56.    H.-C. Hung, G.-G. Chang, Z. Yang & L. Tong. (2000). Slow binding of metal ions to pigeon liver malic enzyme: a general case. Biochem. 39, 14095-14102.

57.    D. Shi, H. Morizono, X. Yu, L. Tong, N. M. Allewell & M. Tuchman. (2001). Crystallization and preliminary X-ray crystallographic studies of wild-type human ornithine transcarbamylase and two naturally occurring mutants at position 277. Acta Cryst. D57, 719-721.

58.    D. Shi, H. Morizono, X. Yu, L. Tong, N. M. Allewell & M. Tuchman. (2001). Human ornithine transcarbamylase: Crystallographic insights into substrate recognition and conformational changes. Biochem. J. 354, 501-509.

59.    S. Rozovsky, G. Jogl, L. Tong & A.E. McDermott. (2001). Solution-state NMR investigations of triosephosphate isomerase active site loop motion: Ligand release in relation to active site loop dynamics. J. Mol. Biol. 310, 271-280.

60.    R. Khayat, R. Batra, M.-J. Massariol, L. Lagace & L. Tong. (2001). Investigating the role of histidine157 in the catalytic activity of human cytomegalovirus protease. Biochem. 40, 6344-6351.

61.    K. Last-Barney, W. Davidson, M. Cardozo, L. L. Frye, C. A. Grygon, J. L. Hopkins, D. D. Jeanfavre, S. Pav, C. Qian, J. M. Stevenson, L. Tong, R. Zindell & T. A. Kelly. (2001). Binding site identification of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: Evidence for the allosteric inhibition of a protein-protein interaction. J. Amer. Chem. Soc. 123, 5643-5650.

62.    G. Jogl, X. Tao, Y. Xu & L. Tong. (2001). COMO: A program for combined molecular replacement. Acta Cryst. D57, 1127-1134.

63.    R. Batra, R. Khayat & L. Tong. (2001). Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. Nature Struct. Biol. 8, 810-817.

64.    M.A. Rishavy, Z. Yang, L. Tong & W.W. Cleland. (2001). Determination of the mechanism of human malic enzyme with natural and alternate dinucleotides by isotope effects. Arch. Biochem. Biophys. 396, 43-48.

65.    Z. Yang, H. Zhang, H.-C. Hung, C.-C. Kuo, L.-C. Tsai, H.S. Yuan, W.-Y. Chou, G.-G. Chang & L. Tong. (2002). Structural studies of pigeon cytosolic NADP+-dependent malic enzyme. Protein Science, 11, 332-341.

66.    C. Pargellis,* L. Tong,* L. Churchill, P.F. Cirillo, T. Gilmore, A.G. Graham, P.M. Grob, E.R. Hickey, N. Moss, S. Pav & J. Regan. (2002). Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nature Struct. Biol. 9, 268-272. (*–co-corresponding authors)

67.    J. Regan, S. Breitfelder, P. Cirillo, T. Gilmore, A.G. Graham, E. Hickey, B. Klaus, J. Madwed, M. Moriak, N. Moss, C. Pargellis, S. Pav, A. Proto, A. Swanimer, L. Tong & C. Torcellini. (2002). Pyrazole urea-based inhibitors of p38 MAP kinase: From lead compound to clinical candidate. J. Med. Chem. 45, 2994-3008.

68.    Z. Yang, C.W. Lanks & L. Tong. (2002). Molecular mechanism for the regulation of human mitochondrial NAD+-dependent malic enzyme by fumarate and ATP. Structure, 10, 951-960.

69.    R. Batra, D. Christendat, A. Edwards, C. Arrowsmith & L. Tong. (2002). Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase. Proteins, 49, 285-288.

70.    G. Jogl, Y. Shen, D. Gebauer, J. Li, K. Wiegmann, H. Kashkar, M. Kronke & L. Tong. (2002). Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain. EMBO J. 21, 4785-4795.

71.    X. Tao, Y. Xu, Y. Zheng, A. Beg & L. Tong. (2002). An extensively-associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. Biochem. Biophys. Res. Commun. 299, 216-221.

72.    G. Jogl & L. Tong. (2003). Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. Cell, 112, 113-122.

73.    G. Jogl, S. Rozovsky, A.E. McDermott & L. Tong. (2003). Optimal alignment for enzymatic proton transfer: Structure of the Michaelis complex of triosephosphate isomerase at 1.2-A resolution. Proc. Natl. Acad. Sci. USA, 100, 50-55.

74.    R. Khayat, R. Batra, C. Qian, T. Halmos, M. Bailey & L. Tong. (2003). Structural and biochemical studies of inhibitor binding to human cytomegalovirus protease. Biochem. 42, 885-891.

75.    Z. Yang, A. Savchenko, A. Yakunin, R. Zhang, A. Edwards, C. Arrowsmith & L. Tong. (2003). Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. J. Biol. Chem. 278, 8804-8808.

76.    H. Zhang, Z. Yang,* Y. Shen* & L. Tong. (2003). Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science, 299, 2064-2067. (*–equal second authors)

77.    X. Tao, R. Khayat, D. Christendat, A. Savchenko, X. Xu, S. Goldsmith-Fischman, B. Honig, A. Edwards, C.H. Arrowsmith & L. Tong. (2003). Crystal structures of MTH1187 and its yeast ortholog YBL001c. Proteins, 52, 478-480.

78.    X. Tao & L. Tong. (2003). Crystal structure of DJ-1, a protein associated with early-onset Parkinson's disease. J. Biol. Chem. 278, 31372-31379.

79.    X. Tao, Z. Yang & L. Tong. (2003). Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism. Structure, 11, 1141-1150.

80.    F. Forouhar, J. Shen, R. Xiao, T.B. Acton, G.T. Montelione & L. Tong. (2003). Functional assignment based on structural analysis: Crystal structure of the yggJ protein (HI0303) of Haemophilus influenzae reveals an RNA methyltransferase with a deep trefoil knot. Proteins. 53, 329-332.

81.    S. Gobin, L. Thuillier, G. Jogl, A. Faye, L. Tong, M. Chi, J.-P. Bonnefont, J. Girard, C. Prip-Buus. (2003). Functional and structural basis of carnitine palmitoyltransferase 1A deficiency. J. Biol. Chem. 278, 50428-50434.

82.    R. Khayat, R. Batra, G.A. Bebernitz, M.W. Olson & L. Tong. (2004). Characterization of the monomer-dimer equilibrium of human cytomegalovirus protease by kinetic methods. Biochem. 43, 316-322.

83.    C.-W. Kuo, H.-C. Hung, L. Tong & G.-G. Chang. (2004). Metal-induced reversible structural interconversion of human mitochondrial NAD(P)+-dependent malic enzyme. Proteins, 54, 404-411.

84.    G. Jogl & L. Tong. (2004). Crystal structure of yeast acetyl-CoA synthetase in complex with AMP. Biochem. 43, 1425-1431.

85.    F. Forouhar, I. Lee, J. Benach, K. Kulkarni, R. Xiao, T.B. Acton, G.T. Montelione & L. Tong. (2004). A novel NAD binding protein revealed by the crystal structure of 2,3-diketo-L-gulonate reductase (YiaK). J. Biol. Chem. 279, 13148-13155.

86.    H. Zhang, B. Tweel & L. Tong. (2004). Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by haloxyfop and diclofop. Proc. Natl. Acad. Sci. USA, 101, 5910-5915.

87.    W.-C. Hsu, H.-C. Hung, L. Tong & G.-G. Chang. (2004). Dual functional roles of ATP in the human mitochondrial malic enzyme. Biochem. 43, 7382-7390.

88.    Y.-H. Chen, M.-H. Li, Y. Zhang, L.-L. He, Y. Yamada, A. Fitzmaurice, Y. Shen, H. Zhang, L. Tong & J. Yang. (2004). Structural basis of a1-b subunit interaction of voltage-gated Ca2+ channels. Nature, 429, 675-680.

89.    Y.-S. Hsiao, G. Jogl & L. Tong. (2004). Structural and biochemical studies of the substrate selectivity of carnitine acetyltransferase. J. Biol. Chem. 279, 31584-31589.

90.    J.A. Khan, E.K. Brint, L.A.J. O'Neill & L. Tong. (2004). Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of IL-1RAPL. J. Biol. Chem. 279, 31664-31670.

91.    H. Zhang, B. Tweel, J. Li & L. Tong. (2004). Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186. Structure, 12, 1683-1691.

92.    R. Hering,* K.M. Strauss,* X. Tao,* A. Bauer, D. Woitalla, E.-M. Mietz, S. Petrovic, P. Bauer, W. Schaible, T. Muller, L. Schols, C. Klein, D. Berg, P.T. Meyer, J.B. Schulz, B. Wollnik, L. Tong, R. Kruger & O. Riess. (2004). Novel homozygous E64D mutation in DJ1 in early onset Parkinson disease (PARK7). Hum. Mutat. 24, 321-329. (*–equal first author)

93.    D. Gebauer,* J. Li,* G. Jogl, Y. Shen, D.G. Myszka & L. Tong. (2004). Crystal structure of the PH-BEACH domains of human LRBA/BGL. Biochem. 43, 14873-14880. (*–equal first authors)

94.    W. Blankenfeldt, A.P. Kuzin, T. Skarina, Y. Korniyenko, L. Tong, P. Beyer, P. Janning, L.S. Thomashow & D.V. Mavrodi. (2004). Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens. Proc. Natl. Acad. Sci. USA, 101, 16431-16436.

95.    Y. Shen, S.L. Volrath, S.C. Weatherly, T.D. Elich & L. Tong. (2004). A mechanism for the potent inhibition of eukaryotic acetyl coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. Mol. Cell, 16, 881-891.

96.    G. Jogl, Y.-S. Hsiao & L. Tong. (2005). Crystal structure of murine carnitine octanoyltransferase and molecular determinants of substrate selectivity. J. Biol. Chem. 280, 738-744.

97.    F. Forouhar, Y. Yang,$ D. Kumar,$ C. Yang, Y. Fridman, S.W. Park, Y. Chiang, T.B. Acton, G.T. Montelione, E. Pichersky,* D.F. Klessig* & L. Tong.* (2005). Structural and biochemical studies identify SABP2 as a methylsalicylate esterase and implicate it in plant innate immunity. Proc. Natl. Acad. Sci. USA, 102, 1773-1778. ($–equal second authors; *–co-corresponding authors)

98.    J.A. Khan, B.M. Dunn & L. Tong. (2005). Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Structure, 13, 1443-1452.

99.    M.J. Rudolph, G.A. Amodeo, Y. Bai & L. Tong. (2005). Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1. Biochem. Biophys. Res. Commun. 337, 1224-1228

100.  F. Forouhar, I.-S. Lee, J. Vujcic, S. Vujcic, J. Shen, S.M. Vorobiev, R. Xiao, T.B. Acton, G.T. Montelione, C.W. Porter & L. Tong. (2005). Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase (SSAT). J. Biol. Chem. 280, 40328-40336.

101.  S.C. Annedi, F. Biabani, E. Poduch, B.M. Mannargudi, K. Majumder, L. Wei, R. Khayat, L. Tong & L.P. Kotra. (2006). Engineering D-amino acid containing novel protease inhibitors using catalytic site architecture. Bioorg. Med. Chem. 14, 214-236.

102.  Y. Shen, C.-Y. Chou, G.-G. Chang & L. Tong. (2006). Is dimerization required for the catalytic activity of bacterial biotin carboxylase? Mol. Cell, 22, 807-818.

103.  J.A. Khan, X. Tao & L. Tong. (2006). Molecular basis for the inhibition of human NMPRTase, a novel target for anti-cancer agents. Nature Struct. Mol. Biol. 13, 582-588. (News & Views 563-564)

104.  Y.-S. Hsiao, G. Jogl, V. Esser & L. Tong. (2006). Crystal structure of rat carnitine palmitoyltransferase II (CPT-II). Biochem. Biophys. Res. Commun. 346, 974-980.

105.  G. Soong, A. Muir, M.I. Gomez, J. Waks, B. Reddy, P. Planet, P.K. Singh, Y. Kaneko, M.C. Wolfgang, Y.-S. Hsiao, L. Tong & A. Prince. (2006). Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production. J. Clin. Invest. 116, 2297-2305.

106.  Y.-S. Hsiao, G. Jogl & L. Tong. (2006). Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates. J. Biol. Chem. 281, 28480-28487.

107.  C.R. Mandel, D. Gebauer, H. Zhang  & L. Tong. (2006). A serendipitous discovery that in situ partial proteolysis is essential for the crystallization of yeast CPSF-100 (Ydh1p). Acta Cryst. F62, 1041-1045.

108.  C.R. Mandel, S. Kaneko,* H. Zhang,* D. Gebauer, V. Vethantham, J.L. Manley & L. Tong. (2006). Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature, 444, 953-956. (*–equal second authors)

109.  F. Forouhar,* J.L.R. Anderson,* C.G. Mowat,* S.M. Vorobiev, A. Hussain, M. Abashidze, C. Bruckmann, S.J. Thackray, J. Seetharaman, T. Tucker, R. Xiao, L.-C. Ma, L. Zhao, T.B. Acton, G.T. Montelione,$ S.K. Chapman$  & L. Tong.$ (2007). Molecular insights into catalysis by tryptophan 2,3-dioxygenase. Proc. Natl. Acad. Sci. USA, 104, 473-478. (*–equal first authors, $–co-corresponding authors)

110.  M.J. Rudolph, G.A. Amodeo, S.H. Iram, S.-P. Hong, G. Pirino, M. Carlson & L. Tong. (2007). Crystal structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding. Structure, 15, 65-74.

111.  S. Xiang, G. Usunow, G. Lange, M. Busch & L. Tong. (2007). Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase (DXS), a crucial enzyme for isoprenoids biosynthesis. J. Biol. Chem. 282, 2676-2682.

112.  Y. Bai, T.C. Auperin & L. Tong. (2007). The use of in situ proteolysis in the crystallization of murine CstF-77. Acta Cryst. F63, 135-138.

113.  S.M. Vorobiev, H. Neely, J. Seetharaman, L.-C. Ma, R. Xiao, T.B. Acton, G.T. Montelione & L. Tong. (2007). Crystal structure of AGR_C_4470p from Agrobacterium tumefaciens. Protein Sci. 16, 535-538.

114.  Y. Bai, T.C. Auperin, C.-Y. Chou, G.-G. Chang, J.L. Manley & L. Tong. (2007). Crystal structure of murine CstF-77: Dimeric association and implications for polyadenylation of mRNA precursors. Mol. Cell, 25, 863-875.

115.  X. Tao & L. Tong. (2007). Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5. Protein Sci. 16, 880-886.

116.  J. Li, X. Mao, L.Q. Dong, F. Liu & L. Tong. (2007). Crystal structures of the BAR-PH and PTB domains of human APPL1. Structure, 15, 525-533.

117.  C. Yin,* J.A. Khan,* G.V.T. Swapna, A. Ertekin, R.M. Krug,$ L. Tong$ & G.T. Montelione.$ (2007). Conserved surface features form the double-stranded RNA-binding site of non-structural proteins 1 (NS1) from influenza A and B viruses. J. Biol. Chem. 282, 20584-20592. (*–equal first authors, $–co-corresponding authors)

118.  J.A. Khan,* S. Xiang* & L. Tong. (2007). Crystal structure of human nicotinamide riboside kinase (NRK1). Structure, 15, 1005-1013. (*–equal first authors)

119.  G.A. Amodeo,* M.J. Rudolph* & L. Tong. (2007). Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature, 449, 492-495. (*–equal first authors)

120.  J. Benach, L. Wang,* Y. Chen,* C.K. Ho, S. Lee, J. Seetharaman, R. Xiao, T.B. Acton, G.T. Montelione, H. Deng, R. Sun$ & L. Tong.$ (2007). Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus-68. J. Biol. Chem. 282, 31534-31541. (*–equal second authors, $–co-corresponding authors)

121.  S. Xiang & L. Tong. (2008). Crystal structures of human and S. aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nature Struct. Mol. Biol. 15, 295-302.

122.  S. Metzger, J. Rong, H.-P. Nguyen, A. Cape, J. Tomiuk, A. Soehn, P. Propping, Y. Freudenberg-Hua, J. Freudenberg, L. Tong, S.-H. Li, X.-J. Li & O. Riess. (2008). Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Human Mol. Genet. 17, 1137-1146.

123.  F. Forouhar, M. Abashidze, H. Xu, L.L. Grochowski, J. Seetharaman, M. Hussain, A. Kuzin, Y. Chen, W. Zhou, R. Xiao, T.B. Acton, G.T. Montelione, A. Galinier, R.H. White & L. Tong. (2008). Molecular insights into the biosynthesis of coenzyme F420. J. Biol. Chem. 283, 11832-11840.

124.  Y. Shen & L. Tong. (2008). Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochem. 47, 5767-5773. (selected as Hot Article)

125.  J.A. Vila, J.M. Aramini, P. Rossi, A. Kuzin, M. Su, J. Seetharaman, R. Xiao, L. Tong, G.T. Montelione & H.A. Scheraga. (2008). Quantum chemical 13Ca chemical shift calculations for protein NMR structure determination, refinement, and validation. Proc. Natl. Acad. Sci. USA, 105, 14389-14394.

126.  S.J. Thackray, C. Bruckmann, J.L.R. Anderson, L.P. Campbell, R. Xiao, L. Zhao, C.G. Mowat, F. Forouhar, L. Tong & S.K. Chapman. (2008). Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding. Biochem. 47, 10677-10684.

127.  Y.J. Huang, D. Hang, L.J. Lu, L. Tong, M.B. Gerstein & G.T. Montelione. (2008). Targeting the human cancer pathway protein interaction network by structural genomics. Mol. Cell. Proteomics, 7, 2048-2060.

128.  S.M. Vorobiev, M. Su, J. Seetharaman, Y.J. Huang, C.X. Chen, M. Maglaqui, H. Janjua, M. Proudfoot, A. Yakunin, R. Xiao, T.B. Acton, G.T. Montelione & L. Tong. (2009). Crystal structure of human retinoblastoma binding protein 9 (RBBP9). Proteins, 74, 526-529.

129.  N. Zhao, J. Guan, F. Forouhar, T.J. Tschaplinski, Z.-M. Cheng, L. Tong & F. Chen. (2009). Two poplar methyl salicylate esterases display comparable biochemical properties but divergent expression patterns. Phytochem. 70, 37-44.

130.  S.-W. Park, P.-P. Liu, F. Forouhar, A.C. Vlot, L. Tong, K. Tietjen & D.F. Klessig. (2009). Use of a synthetic salicylic acid analog to investigate the roles of methyl salicylate and its esterases in plant disease resistance. J. Biol. Chem. 284, 7307-7317.

131.  Y.-S. Hsiao, D. Parker, A.J. Ratner, A. Prince & L. Tong. (2009). Crystal structures of respiratory pathogen neuraminidases. Biochem. Biophys. Res. Commun. 380, 467-471.

132.  C. Bertonati, M. Punta, M. Fischer, G. Yachdav, F. Forouhar, W. Zhou, A.P. Kuzin, J. Seetharaman, M. Abashidze, T.A. Ramelot, M.A. Kennedy, J.R. Cort, A. Belachew, J.F. Hunt, L. Tong, G.T. Montelione & B. Rost. (2009). Structural genomics reveals EVE as a new ASCH/PUA-related domain. Proteins, 75, 760-773.

133.  S. Xiang, A. Cooper-Morgan, X. Jiao, M. Kiledjian, J.L. Manley & L. Tong. (2009). Structure and function of the 5'-3' exoribonuclease Rat1 and its activating partner Rai1. Nature, 458, 784-788.

134.  C.-Y. Chou, L.P.C. Yu & L. Tong. (2009). Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism. J. Biol. Chem. 284, 11690-11697.

135.  L.P.C. Yu, S. Xiang, G. Lasso, D. Gil, M. Valle & L. Tong. (2009). A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure, 17, 823-832.

136.  C.R. Mandel, B. Tweel & L. Tong. (2009). Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2). Biochem. Biophys. Res. Commun. 385, 630-633.

137.  Y. Yu, M.H. Ulbrich, M.-H. Li, Z. Buraei, X.-Z. Chen, A.C.M. Ong, L. Tong, E.Y. Isacoff & J. Yang. (2009). Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc. Natl. Acad. Sci. USA, 106, 11558-11563.

138.  F. Sinturel, O. Pellegrini, S. Xiang, L. Tong, C. Condon & L. Benard. (2009). Real-time fluorescence detection of exoribonucleases. RNA, 15, 2057-2062.

139.  S. Xiang, M.M. Callaghan, K.G. Watson & L. Tong. (2009). A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proc. Natl. Acad. Sci. USA, 106, 20723-20727.

140.  J.W. Corbett, K.D. Freeman-Cook, R. Elliot, F. Vajdos, F. Rajamohan, D. Kohls, E. Marr, H. Zhang, L. Tong, M. Tu, S. Murdande, S.D. Doran, J.A. Houser, W. Song, C.J. Jones, S.B. Coffey, L. Buzon, M.L. Minich, K.J. Dirico, S. Tapley, R.K. McPherson, E. Sugarman, H.J. Harwood & W. Esler. (2010). Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg. Med. Chem. Lett. 20, 2383-2388.

141.  G.A. Amodeo, M. Momcilovic, M. Carlson & L. Tong. (2010). Biochemical and functional studies on the regulation of the Saccharomyces cerevisiae AMPK homolog SNF1. Biochem. Biophys. Res. Commun. 397, 197-201.

142.  P.M. Manosalva, S.-W. Park, F. Forouhar, L. Tong, W.E. Fry & D.F. Klessig. (2010). Methyl esterase 1 (StMES1) is required for systemic acquired resistance in potato. Mol. Plant Microbe Interactions, 23, 1151-1163.

143.  M.J. Rudolph, G.A. Amodeo & L. Tong. (2010). An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1. Acta Cryst. F66, 999-1002.

144.  S. Metzger, M. Saukko, H. van Che, L. Tong, Y. Puder, O. Riess & H.P. Nguyen. (2010). Age at onset in Huntington's disease is modified by the autophagy pathway: Implication of the V471A polymorphism in Atg7. Hum. Genet. 128, 453-459.

145.  G. Lasso, L.P.C. Yu, D. Gil, S. Xiang, L. Tong & M. Valle. (2010). Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase. Structure, 18, 1300-1310.

146.  F. Forouhar, S. Lew, J. Seetharaman, R. Xiao, T.B. Acton, G.T. Montelione & L. Tong. (2010). Crystal structures of bacterial biosynthetic arginine decarboxylases. Acta Cryst. F66, 1562-1566.

147.  L.P.C. Yu, Y.S. Kim & L. Tong. (2010). Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden. Proc. Natl. Acad. Sci. USA, 107, 22072-22077.

148.  C.S. Huang,* K. Sadre-Bazzaz,* Y. Shen, B. Deng, Z.H. Zhou & L. Tong. (2010). Crystal structure of the a6b6 holoenzyme of propionyl-coenzyme A carboxylase. Nature, 466, 1001-1005. (*–equal first authors)

149.  X. Jiao, S. Xiang, C.-S. Oh, C.E. Martin, L. Tong & M. Kiledjian. (2010). Identification of a quality-control mechanism for eukaryotic mRNA 5'-end capping. Nature, 467, 608-611.

150.  K. Xiang, T. Nagaike,* S. Xiang,* T. Kilic, M.M. Beh, J.L. Manley & L. Tong. (2010). Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature, 467, 729-733. (*–equal second authors)

151.  A.W. Barb, J.R. Cort, J. Seetharaman, S. Lew, H.-W. Lee, T.B. Acton, R. Xiao, M.A. Kennedy, L. Tong, G.T. Montelione & J.H. Prestegard. (2011). Structures of domains I and IV from YbbR are representative of a widely distributed protein family. Protein Sci. 20, 396-405.

152.  Y. Bai, S.K. Srivastava, J.H. Chang, J.L. Manley & L. Tong. (2011). Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Mol. Cell, 41, 311-320.

153.  J.H. Chang,* S. Xiang,* K. Xiang, J.L. Manley & L. Tong. (2011). Structural and biochemical studies of the 5'-3' exoribonuclease Xrn1. Nature Struct. Mol. Biol. 18, 270-276. (*–equal first authors)

154.  K.Y. Huang, G.A. Amodeo, L. Tong & A.E. McDermott. (2011). The structure of human ubiquitin in 2-methyl-2,4-pentanediol: A new conformational switch. Protein Sci. 20, 630-639.

155.  C.-Y. Chou & L. Tong. (2011). Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization. J. Biol. Chem. 286, 24417-24425.

156.  H. Zhang,* R. Constantine,* S. Vorobiev, Y. Chen, J. Seetharaman, Y.J. Huang, R. Xiao, G.T. Montelione, C.D. Gerstner, M.W. Davis, G. Inana, F.G. Whitby, E.M. Jorgensen, C.P. Hill, L. Tong & W. Baehr. (2011). UNC119 is required for G protein trafficking in sensory neurons. Nature Neurosci. 14, 874-880. (*–equal first authors)

157.  J. Lowery,* T. Szul,* J. Seetharaman,* X. Jian,* M. Su, F. Forouhar, R. Xiao, T.B. Acton, G.T. Montelione, H. Lin, J.W. Wright, E. Lee, Z.G. Holloway, P.A. Randazzo, L. Tong & E. Sztul. (2011). Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation. J. Biol. Chem. 286, 36898-36906. (*–equal first authors)

158.  F. Forouhar, N. Saadat, M. Hussain, J. Seetharaman, I. Lee, H. Janjua, R. Xiao, R. Shastry, T.B. Acton, G.T. Montelione & L. Tong. (2011). A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding. Acta Cryst. F67, 1323-1327.

159.  A. Kryshtafovych, J. Moult, S.G. Bartual, J.F. Bazan, H. Berman, D.E. Casteel, E. Christodoulou, J.K. Everett, J. Hausmann, T. Heidebrecht, T. Hills, R. Hui, J.F. Hunt, J. Seetharaman, A. Joachimiak, M.A. Kennedy, C. Kim, A. Lingel, K. Michalska, G.T. Montelione, J.M. Otero, A. Perrakis, J.C. Pizarro, M.J. van Raaij, T.A. Ramelot, F. Rousseau, L. Tong, A.K. Wernimont, J. Young & T. Schwede. (2011). Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins, 79, Suppl 10:6-20.

160.  S. Ni, M.E. McGookey, S.L. Tinch, A.N. Jones, S. Jayaraman, L. Tong & M.A. Kennedy. (2011). The 1.7 A resolution structure of At2g44920, a pentapeptide repeat protein in the thylakoid lumen of Arabidopsis thaliana. Acta Cryst. F67, 1480-1484.

161.  A.A. Aksyuk, L.P. Kurochkina, A. Fokine, F. Forouhar, V.V. Mesyanzhinov, L. Tong & M.G. Rossmann. (2011). Structural conservation of the myoviridae phage tail sheath protein fold. Structure, 19, 1885-1894.

162.  C.S. Huang, P. Ge, Z.H. Zhou & L. Tong. (2012). An unanticipated architecture of the 750-kDa a6b6 holoenzyme of 3-methylcrotonyl-CoA carboxylase. Nature, 481, 219-223.

163.  L. Wang, K. Zhang, L. Wu, S. Liu, H. Zhang, Q. Zhou, L. Tong, F. Sun* & Z. Fan*. (2012). Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif. J. Immunol. 188, 765-773. (*–co-corresponding authors)

164.  L. Wang, H. Guo, N. Reyes, S. Lee, E. Bortz, F. Guo, R. Sun, L. Tong & H. Deng. (2012). Distinct domains in ORF52 tegument protein mediate essential functions in murine gammaherpesvirus 68 virion tegumentation and secondary envelopment. J. Virol. 86, 1348-1357.

165.  C. Fan, C.-Y. Chou, L. Tong & S. Xiang. (2012). Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction. J. Biol. Chem. 287, 9389-9398.

166.  A.R. Paulson & L. Tong. (2012). Crystal structure of the Rna14-Rna15 complex. RNA, 18, 1154-1162.

167.  K. Xiang, J.L. Manley & L. Tong. (2012). The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nature Commun. 3, 946. doi: 10.1038/ncomms1947.

168.  E.A. Feldmann, J. Seetharaman, T.A. Ramelot, S. Lew, L. Zhao, K. Hamilton, C. Ciccosanti,  R. Xiao, T.B. Acton, J.K. Everett, L. Tong, G.T. Montelione & M.A. Kennedy. (2012). Solution NMR and X-ray crystal structure of Pseudomonas syringae Pspto_3016 from protein domain family PF04237 (DUF419) adopts a "double wing" DNA binding motif. J. Struct. Funct. Genomics, 13, 155-162.

169.  G.V.T. Swapna, P. Rossi, A.F. Montelione, J. Benach, B. Yu, M. Abashidze, J. Seetharaman, R. Xiao, T.B. Acton, L. Tong & G.T. Montelione. (2012). Three structural representatives of the PF06855 protein domain family from Staphyloccocus aureus and Bacillus subtilis have SAM domain-like folds and different functions. J. Struct. Funct. Genomics, 13, 163-170.

170.  V. de Crecy-Lagard,* F. Forouhar, C. Brochier-Armanet, L. Tong & J.F. Hunt. (2012). Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage. Biology Direct, 7, 32. (*–corresponding author)

171.  F. Richter*, R. Blomberg*, S.D. Khare, G. Kiss, A.P. Kuzin, A.J.T. Smith, J. Gallaher, Z. Pianowski, R.C. Helgeson, A. Grjasnow, R. Xiao, J. Seetharaman, M. Su, S. Vorobiev, S. Lew, F. Forouhar, G.J. Kornhaber, J.F. Hunt, G.T. Montelione, L. Tong, K.N. Houk, D. Hilvert & D. Baker. (2012). Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. J. Amer. Chem. Soc. 134, 16197-16206. (*–equal first authors)

172.  J.H. Chang,* X. Jiao,* K. Chiba, C.-S. Oh, C.E. Martin, M. Kiledjian$ & L. Tong.$ (2012). Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activities. Nature Struct. Mol. Biol. 19, 1011-1017. (*–equal first authors, $–co-corresponding authors) (Research Highlight in Nature Chem. Biol. Nov. 2012)

173.  K. Xiang, J.L. Manley & L. Tong. (2012). An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Develop. 26, 2265-2270.

174.  Y. Yu, M.H. Ulbrich, M.-H. Li, S. Dobbins, W.K. Zhang, L. Tong, E.Y. Isacoff & J. Yang. (2012). Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nature Commun. 3, 1252. doi: 10.1038/ncomms2257.

175.  D. Tan, W.F. Marzluff, Z. Dominski & L. Tong. (2013). Structure of histone mRNA stem-loop, human stem-loop binding protein and 3'hExo ternary complex. Science, 339, 318-321.

176.  L. Wang,* Q. Li,* L. Wu, S. Liu, Y. Zhang, X. Yang, P. Zhu, H. Zhang, K. Zhang, J. Lou, P. Liu, L. Tong,$ F. Sun,$ & Z. Fan.$ (2013). Identification of SERPINB1 as a physiological inhibitor of human granzyme H. J. Immunol. 190, 1319-1330. (*–equal first authors, $–co-corresponding authors) (featured in 'In This Issue', p. 845)

177.  L.P.C. Yu, C.-Y. Chou, P.H. Choi & L. Tong. (2013). Characterizing the importance of the biotin carboxylase domain dimer for S. aureus pyruvate carboxylase catalysis. Biochem. 52, 488-496.

178.  X. Jiao,* J.H. Chang,* T. Kilic, L. Tong$ & M. Kiledjian.$ (2013). A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Mol. Cell, 50, 104-115. (*–equal first authors, $–co-corresponding authors) (Preview by J.S. Mugridge & J.D. Gross, 2-4)

179.  D. Tan, W.M. Crabb, W.B. Whitman & L. Tong. (2013). Crystal structure of DmdD, a crotonase superfamily enzyme that catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA. PLoS One, 8, e63870.

180.  D.S. Froese,* F. Forouhar,* T.H. Tran,* M. Vollmar, Y.S. Kim, S. Lew, H. Neely, J. Seetharaman, Y. Shen, R. Xiao, T.B. Acton, J.K. Everett, G. Cannone, S. Puranik, P. Savitsky, T. Krojer, E.S. Pilka, W. Kiyani, W.H. Lee, B.D Marsden, F. von Delft, C.K. Allerston, L. Spagnolo, O. Gileadi, G.T. Montelione, U. Oppermann, W.W. Yue$ & L. Tong.$ (2013). Crystal structures of malonyl-CoA decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure, 21, 1182-1192. (*–equal first authors, $–co-corresponding authors)

181.  S.Y. Xu,*$ A.P. Kuzin,* J. Seetharaman, A. Gutjahr, S.H. Chan, Y. Chen, R. Xiao, T.B. Acton, G.T. Montelione & L. Tong.$ (2013). Structure determination and biochemical characterization of a putative HNH endonuclease from Geobacter metallireducens GS-15. PLoS One, 8, e72114. (*–equal first authors, $–co-corresponding authors)

182.  E. Procko, R. Hedman, K. Hamilton, J. Seetharaman, S.J. Fleishman, M. Su, J.M. Aramini, G.J. Kornhaber, J.F. Hunt, L. Tong, G.T. Montelione & D. Baker. (2013). Computational design of a protein-based enzyme inhibitor. J. Mol. Biol. 425, 3563-3575.

183.  J.H. Mills, S.D. Khare, J.M. Bolduc, F. Forouhar, V.K. Mulligan, S. Lew, J. Seetharaman, L. Tong, B.L. Stoddard & D. Baker. (2013). Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy. J. Amer. Chem. Soc. 135, 13393-13399.

184.  J. Catalano, K. Sadre-Bazzaz, G.A. Amodeo, L. Tong & A.E. McDermott. (2013). Structural evidence: A single charged residue affects substrate binding in cytochrome P450 BM-3. Biochem. 52, 6807-6815.

185.  T.K. Neklesa,* D.J. Noblin,* A.P. Kuzin, S. Lew, J. Seetharaman, T.B. Acton, G.J. Kornhaber, R. Xiao, G.T. Montelione, L. Tong & C.M. Crews (2013). A bidirectional system for the dynamic small molecule control of intracellular fusion proteins. ACS Chem. Biol. 8, 2293-2300. (*–equal first authors)

186.  L. Meng*, F. Forouhar*, D. Thieker, Z. Gao, A. Ramiah, H. Moniz, Y. Xiang, J. Seetharaman, S. Milaninia, M. Su, R. Bridger, L. Veillon, P. Azadi, G. Kornhaber, L. Wells, G.T. Montelione, R.J. Woods,$ L. Tong$ & K.W. Moremen$ (2013). Enzymatic basis for N-glycan sialylation: structure of rat a2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. J. Biol. Chem. 288, 34680-34698. (*–equal first authors, $–co-corresponding authors)

187.  H. Yang, T. Zhang, Y. Tao, F. Wang, L. Tong & J. Ding. (2013). Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. Nucl. Acids Res. 41, 10573-10583.

188.  S. Bjelic, Y. Kipnis, L. Wang, Z. Pianowski, S. Vorobiev, M. Su, J. Seetharaman, R. Xiao, G.J. Kornhaber, J.F. Hunt, L. Tong, D. Hilvert & D. Baker. (2014). Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J. Mol. Biol. 426, 256-271.

189.  S.M. Vorobiev*, Y. Gensler*, H. Vahedian-Movahed, J. Seetharaman, M. Su, J.Y. Huang, R. Xiao, G.J. Kornhaber, G.T. Montelione, L. Tong, R.H. Ebright$ & B.E. Nickels.$ (2014). Structure of the DNA-binding and RNA-polymerase-binding region of transcription antitermination factor lQ. Structure, 22, 488-495. (*–equal first authors, $–co-corresponding authors)

190.  B. Srinivasan,* F. Forouhar,* A. Shukla, C. Sampangi, S. Kulkarni, M. Abashidze, J. Seetharaman, S. Lew, L. Mao, T.B. Acton, R. Xiao, J.K. Everett, G.T. Montelione, L. Tong$ & H. Balaram.$ (2014). Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila. FEBS J. 281, 1613-1628. (*–equal first authors, $–co-corresponding authors)

191.  X. Yang,* M. Xu,* Y. Wang, P. Xia, S. Wang, B. Ye, L. Tong$, T. Jiang$ & Z. Fan.$ (2014). Molecular mechanism for self-protection against the type VI secretion system in Vibrio cholerae. Acta Cryst. D70, 1094-1103. (*–equal first authors, $–co-corresponding authors)

192.  R. Wang,* K. Rajagopalan,* K. Sadre-Bazzaz, M. Moreau, D.F. Klessig & L. Tong. (2014). Structure of the Arabidopsis thaliana TOP2 oligopeptidase. Acta Cryst. F70, 555-559. (*–equal first authors)

193.  S.Y. Hua,* A. Syed, T.C. Auperin & L. Tong. (2014). The cytoplasmic domain of rat synaptotagmin I enhances synaptic transmission. Cell. Mol. Neurobiol. 34, 659-667. (*–corresponding author)

194.  G. Lasso, L.P.C. Yu, D. Gil, M. Lazaro, L. Tong & M. Valle. (2014). Functional conformations for pyruvate carboxylase during catalysis explored by cryoelectron microscopy. Structure, 22, 911-922.

195.  J. Zhang, D. Tan, E.F. DeRose, L. Perera, Z. Dominski, W.F. Marzluff,* L. Tong* & T.M. Tanaka Hall.* (2014). Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation. Proc. Natl. Acad. Sci. USA, 111, E2937-E2946. (*–co-corresponding authors)

196.  D. Tan, M. Zhou, M. Kiledjian & L. Tong. (2014). The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Nature Struct. Mol. Biol. 21, 679-685.

197.  K. Sureka,* P.H. Choi,* M. Precit, M. Delince, D.A. Pensinger, T.N. Huynh, A.R. Jurado, Y.A. Goo, M. Sadilek, A.T. Iavarone, J.-D. Sauer, L. Tong$ & J.J. Woodward.$ (2014). The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function. Cell, 158, 1389-1401. (*–equal first authors, $–co-corresponding authors)

198.  S. Luo & L. Tong. (2014). Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain. Proc. Natl. Acad. Sci. USA, 111, 13834-13839.

199.  S.I. Elshahawi, T.A. Ramelot, J. Seetharaman, J. Chen, S. Singh, Y. Yang, K. Pederson, M.K. Kharel, R. Xiao, S. Lew, R.M. Yennamalli, M.D. Miller, F. Wang, L. Tong, G.T. Montelione, M.A. Kennedy, C.A. Bingman, H. Zhu, G.N. Phillips Jr* & J.S. Thorson.* (2014). Structure-guided functional characterization of enediyne self-sacrifice resistance proteins CalU16 and CalU19. ACS Chem. Biol. 9, 2347-2358. (*–co-corresponding authors)

200.  W.C. Wilson, H.-T. Hornig-Do, F. Bruni, J.H. Chang, A.A. Jourdain, J.-C. Martinou, M. Falkenberg, H. Spahr, N.-G. Larsson, R.J. Lewis, L. Hewitt, A. Basle, H.E. Cross, L. Tong, R.R. Lebel, A.H. Crosby, Z.M.A. Chrzanowska-Lightowlers* & R.N. Lightowlers.* (2014). A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Human Mol. Genet. 23, 6345-6355. (*–co-corresponding authors)

201.  D.C. Lohman*, F. Forouhar*, E.T. Beebe, M.S. Stefely, C.E. Minogue, A. Ulbrich, J.A. Stefely, S. Sukumar, M. Luna-Sanchez, A. Jochem, S. Lew, J. Seetharaman, R. Xiao, H. Wang, M.S. Westphall, R.L. Wrobel, J.K. Everett, J.C. Mitchell, L.C. López, J.J. Coon, L. Tong$ & D.J. Pagliarini.$ (2014). Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. Proc. Natl. Acad. Sci. USA, 111, E4697-E4705. (*–equal first authors, $–co-corresponding authors)

202.  T.H. Tran, Y.-S. Hsiao, J. Jo, C.-Y. Chou, L.E.P. Dietrich, T. Walz & L. Tong. (2015). Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase. Nature, 518, 120-124.

203.  T.N. Huynh*, S. Luo*, D.A. Pensinger, J.-D. Sauer, L. Tong$ & J.J. Woodward.$. (2015). An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence. Proc. Natl. Acad. Sci. USA, 112, E747-E756. (*–equal first authors, $–co-corresponding authors)

204.  P.H. Choi*, K. Surekha*, J.J. Woodward$ & L. Tong.$ (2015). Molecular basis for the recognition of cyclic-di-AMP by PstA, a PII-like signal transduction protein. MicrobiologyOpen, 4, 361-374. (*–equal first authors, $–co-corresponding authors)

205.  M. Mompean, R. Hervas, Y. Xu, T.H. Tran, C. Guarnaccia, E. Buratti,  F. Baralle, L. Tong, M. Carrion-Vazquez, A.E. McDermott & D.V. Laurents. (2015). Structural evidence of amyloid fibril formation in the putative aggregation domain of TDP-43. J. Phys. Chem. Lett. 6, 2608-2615.

206.  B.A. Webb,* F. Forouhar,* F.-E. Szu, J. Seetharaman, L. Tong$ & D.L. Barber.$ (2015). Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature, 523, 111-114. (*–equal first authors, $–co-corresponding authors)

207.  V.Y.F. Wang, X. Jiao, M. Kiledjian & L. Tong. (2015). Structural and biochemical studies of the distinct activity profiles of Rai1 proteins. Nucl. Acids Res. 43, 6596-6606.

208.  J.M. Aramini,*$ S.M. Vorobiev,* L.M. Tuberty, H. Janjua, E.T. Campbell, J. Seetharaman, M. Su, Y.J. Huang, T.B. Acton, R. Xiao, L. Tong & G.T. Montelione.$ (2015). The RAS-binding domain of human BRAF protein serine/threonine kinase exhibits allosteric conformational changes upon binding HRAS. Structure, 23, 1382-1393. (*–equal first authors, $–co-corresponding authors)

209.  F.S. Katz,*$ S. Pecic,* T.H. Tran*, I. Trakht,* L. Schneider, Z. Zhu, L. Ton-That, M. Luzac, V. Zlatanic, S. Damera, J. Macdonald, D.W. Landry, L. Tong$ & M.N. Stojanovic. (2015). Discovery of new classes of compounds that reactivate acetylcholinesterase inhibited by organophosphates. ChemBiochem, 16, 2205-2215. (*–equal first authors, $–co-corresponding authors) (Cover article)

210.  J. Wei & L. Tong. (2015). Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer. Nature, 526, 723-727.

211.  A.R. Jurado,* C.S. Huang,* X. Zhang, Z.H. Zhou & L. Tong. (2015). Structure and substrate selectivity of the 750-kDa a6b6 holoenzyme of geranyl-CoA carboxylase. Nature Commun. 6, 8986. (*–equal first authors)

212.  M. Sanso, R.S. Levin, J.J. Lipp, V.Y.F. Wang, A.K. Greifenberg, E.M. Quezada, A. Ali, A. Ghosh, S. Larochelle, T.M. Rana, M. Geyer, L. Tong, K.M. Shokat & R.P. Fisher. (2016). P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Develop. 30, 117-131.

213.  G. Harriman, J. Greenwood, S. Bhat, X. Huang, R. Wang, D. Paul, L. Tong, A.K. Saha, W.F. Westlin, R. Kapeller & H.J. Harwood Jr. (2016). Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc. Natl. Acad. Sci. USA, 113, E1796-E1805.

214.  Y. Zhang, K. Rataj, G.G. Simpson & L. Tong. (2016). Crystal structure of the SPOC domain of the Arabidopsis flowering regulator FPA. PLoS One, 11, e0160694.

215.  C. Shan,* J. Wang,* K. Xu,* H. Chen, J.X. Yue, S. Andrews, J.J. Moresco, J.R. Yates III, P.L. Nagy, L. Tong$ & S. Jia.$ (2016). A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. eLife, 5, e17903. (*–equal first authors, $–co-corresponding authors)

216.  T.N. Huynh*, P.H. Choi*, K. Sureka, H.E. Ledvina, J. Campillo, L. Tong$ & J.J. Woodward.$ (2016). Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC. Mol. Microbiol. 102, 233-243. (*–equal first authors, $–co-corresponding authors)

217.  P.H. Choi, J. Jo, Y.C. Lin, M.-H. Lin, C.-Y. Chou, L.E.P. Dietrich & L. Tong. (2016). A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nature Commun. 7, 12713.

218.  A. Lewis-Ballester,* F. Forouhar,* S.M. Kim, S. Lew, Y.Q. Wang, S. Karkashon, J. Seetharaman, D. Batabyal, B.-Y. Chiang, M. Hussain, M.A. Correia, S.-R. Yeh$ & L. Tong.$ (2016). Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Scientific Reports, 6, 35169. (*–equal first authors, $–co-corresponding authors)

219.  Z. Liu,* C. Gutierrez-Vargas,* J. Wei,* R.A. Grassucci, M. Ramesh, N. Espina, M. Sun, B. Tutuncuoglu, S. Madison-Antenucci, J.L. Woolford Jr., L. Tong & J. Frank. (2016). Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit. Proc. Natl. Acad. Sci. USA, 113, 12174-12179. (*–equal first authors)

220.  J. Wei, Y. Zhang, T.-Y. Yu, K. Sadre-Bazzaz, M.J. Rudolph, G.A. Amodeo, L.S. Symington, T. Walz & L. Tong. (2016). A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation. Cell Discovery, 2, 16044.

221.  Y. Zhu,* S. Luo,* Y. Sabo, C. Wang, L. Tong$ & S.P. Goff. $ (2017). Heme oxygenase 2 binds myristate to regulate retrovirus assembly and TLR4 signaling. Cell Host & Microbe, 21, 220-230. (*-equal first authors, $-co-corresponding authors) (Preview by M.D. Resh, HO-2 pockets myristoylated Gag, 131-133).

222.  S. Luo & L. Tong. (2017). Molecular mechanism for the regulation of yeast separase by securin. Nature, 542, 255-259.

223.  M.E. Welsch, A. Kaplan, J.M. Chambers, M.E. Stokes, P.H. Bos, A. Zask, Y. Zhang, M. Sanchez-Martin, M.A. Badgley, C.S. Huang, T.H. Tran, H. Akkiraju, L.M. Brown, R. Nandakumar, S. Cremers, W.S. Yang, L. Tong, K.P. Olive, A. Ferrando & B.R. Stockwell. (2017). Multivalent small-molecule pan-RAS inhibitors. Cell, 168, 878-889.

224.  Y. Zhang,* C. Shan,* J. Wang,* K. Bao, L. Tong$ & S. Jia.$ (2017). Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation. Scientific Reports, 7, 43906. (*-equal first authors, $-co-corresponding authors)

225.  M. Li,* W.K. Zhang,* N.M. Benvin,* X. Zhou, D. Su, H. Li, S. Wang, I.E. Michailidis, L. Tong, X. Li & J. Yang. (2017). Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel. Nature Struct. Mol. Biol. 24, 205-213. (*-equal first authors)

226.  X. Jiao, S. Doamekpor, J.G. Bird, B.E. Nickels, L. Tong, R.P. Hart & M. Kiledjian. (2017). 5' end nicotinamide adenine dinucleotide cap in human cells promotes RNA decay through DXO-mediated deNADding. Cell, 168, 1015-1027.

227.  A.P. McFarland, S. Luo, F. Ahmed-Qadri, M. Zuck, E.F. Thayer, Y.A. Goo, K. Hybiske, L. Tong & J.J. Woodward. (2017). Sensing of bacterial cyclic dinucleotides by the oxidoreductase RECON promotes NF-kB activation and shapes a proinflammatory antibacterial state. Immunity, 46, 433-445.

228.  A.T. Whiteley, N.E. Garelis, B.N. Peterson, P.H. Choi, L. Tong, J.J. Woodward & D.A. Portnoy. (2017). c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance, and osmoregulation. Mol. Microbiol., 104, 212-233.

229.  Y. Wu,* T.R. Albrecht,* D. Baillat, E.J. Wagner$ & L. Tong.$ (2017). Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance. Proc. Natl. Acad. Sci. USA, 114, 4394-4399. (*-equal first authors, $-co-corresponding authors)

230.  P. Xia,* J. Liu,* S. Wang,* B. Ye, Y. Du, Z. Xiong, Z.-G. Han, L. Tong & Z. Fan. (2017). WASH maintains NKp46+ ILC3 cells by promoting AHR expression. Nature Commun. 8, 15685. (*-equal first authors)

231.  R. Maderbocus, B.L. Fields, K. Hamilton, S. Luo, T.H. Tran, L.E.P. Dietrich & L. Tong. (2017). Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer. Nature Commun. 8, 160.

232.  P.H. Choi, T.M.N. Vu, H.T. Pham, J.J. Woodward, M.S. Turner & L. Tong. (2017). Structural and functional studies of pyruvate carboxylase regulation by cyclic-di-AMP in lactic acid bacteria. Proc. Natl. Acad. Sci. USA, 114, E7226-E7235.

233.  W.S. Aik, M.-H. Lin, D. Tan, A. Tripathy, W.F. Marzluff, Z. Dominski, C.-Y. Chou & L. Tong. (2017). The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. PLoS One, 12, e0186034.

234.  R.T. Rogawski, I.V. Sergeyev, Y. Zhang, T.H. Tran, Y. Li, L. Tong & A.E. McDermott. (2017). NMR signal quenching from bound biradical affinity reagents in DNP samples. J. Phys. Chem. B. 121, 10770-10781.

235.  K.W. Moremen,$ A. Ramiah, M. Stuart, J. Steel, L. Meng, F. Forouhar, H.A. Moniz, G. Gahlay, Z. Gao, D. Chapla, S. Wang, J.-Y. Yang, P.K. Prabahkar, R. Johnson, M. dela Rosa, C. Geisler, A.V. Nairn, J. Seetharaman, S.-C. Wu, L. Tong, H.J. Gilbert, J. LaBaer & D.L. Jarvis.$ (2018). Expression system for structural and functional studies of human glycosylation enzymes. Nature Chem. Biol. 14, 156-162. ($-co-corresponding authors)

236.  Y. Sun,* Y. Zhang,* K. Hamilton, J.L. Manley,$ Y. Shi, T. Walz$ & L. Tong.$ (2018). Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. USA, 115, E1419-E1428. (*-equal first authors, $-co-corresponding authors)

237.  T.R. Albrecht, S.P. Shevtsov, Y. Wu, L.G. Mascibroda, N.J. Peart, K.-L. Huang, I.A. Sawyer, L. Tong, M. Dundr$ & E.J. Wagner.$ (2018). Integrator subunit 4 is a 'symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Nucl. Acids Res. 46, 4241-4255. ($-co-corresponding authors)

238.  C.L. Dieck,* G. Tzoneva,* F. Forouhar,* Z. Carpenter, A. Ambesi-Impiombato, M. Sanchez-Martin, R. Kirschner-Schwabe, S. Lew, J. Seetharaman, L. Tong$ & A.A. Ferrando.$ (2018). Mechanisms of NT5C2 activating mutations driving thiopurine resistance in relapsed lymphoblastic leukemia. Cancer Cell, 34, 136-147. (*-equal first authors, $-co-corresponding authors) (Cover article, highlighted in Research Watch of Cancer Discovery)

239.  S.K. Taylor,$ T.H. Tran, M.Z. Liu, P.E. Harris, Y. Sun, S.R. Jambawalikar, L. Tong$ & M.N. Stojanovic.$ (2018). Insulin hexamer-caged gadolinium ion as MRI contrast-o-phore. Chem. Eur. J. 24, 10646-10652. ($-co-corresponding authors) (Frontispiece)

240.  J.-S. Yun,* J.-H. Yoon,* Y.J. Choi, Y.J. Son, S.H. Kim, L. Tong$ & J.H. Chang.$ (2018). Molecular mechanism for the inhibition of DXO by adenosine 3',5'-bisphosphate. Biochem. Biophys. Res. Commun. 504, 89-95. (*-equal first authors, $-co-corresponding authors)

241.  S. Luo, K. Xu, S. Xiang, J. Chen, C. Chen, C. Guo, Y. Tong & L. Tong. (2018). High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Cryst. F74, 717-724.

242. J. Wei, S. Leit, J. Kuai, E. Therrien, S. Rafi, H.J. Harwood Jr, B. DeLaBarre & L. Tong. (2019). An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature, 568, 566-570.

243. A. Kwasnik,*$ V.Y.F. Wang,* M. Krzyszton, A. Gozdek, M. Zakrzewska-Placzek, K. Stepniak, J. Poznanski, L. Tong$ & J. Kufel.$ (2019). Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity. Nucl. Acids Res. 47, 4751-4764. (*-equal first authors, $-co-corresponding authors)

244. E. Grudzien-Nogalska,* Y. Wu,* X. Jiao, H. Cui, M.K. Mateyak, R.P. Hart, L. Tong$ & M. Kiledjian.$ (2019). Structural and mechanistic basis of mammalian Nudt12 deNADding. Nat. Chem. Biol. 15, 575-582. (*-equal first authors, $-co-corresponding authors)

245. Y. Zhang, Y. Chun, S. Buratowski & L. Tong. (2019). Identification of three sequence motifs in the transcription termination factor Sen1 that mediate direct interactions with Nrd1. Structure, 27, 1156-1161.

246. K. Hamilton, Y. Sun & L. Tong. (2019). Biophysical characterizations of the recognition of the AAUAAA polyadenylation signal. RNA, 25, 1673-1680.

247. S.K. Doamekpor,* A. Gozdek,* A. Kwasnik, J. Kufel$ & L. Tong.$ (2020). A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes. Nucl. Acids Res. 48, 349-358. (Epub 11/28/19) (*-equal first authors, $-co-corresponding authors)

248. G.W. Grime, O.B. Zeldin, M.E. Snell, E.D. Lowe, J.F. Hunt, G.T. Montelione, L. Tong, E.H. Snell$ & E.F. Garman.$ (2020). High-throughput PIXE as an essential quantitative assay for accurate metalloprotein structural analysis; development and application. J. Amer. Chem. Soc. 142, 185-197. ($-co-corresponding authors)

249. Y. Sun,* Y. Zhang,* W.S. Aik, X.-C. Yang, W.F. Marzluff, T. Walz$, Z. Dominski$ & L. Tong.$ (2020). Structure of an active human histone pre-mRNA 3'-end processing machinery. Science, 367, 700-703. (*-equal first authors, $-co-corresponding authors)

250. K. Bucholc,* W.S. Aik,* X.-C. Yang, K. Wang, Z.H. Zhou, M. Dadlez, W.F. Marzluff, L. Tong$ & Z. Dominski.$ (2020). Composition and processing activity of a semi-recombinant holo U7 snRNP. Nucl. Acids Res. 48, 1508-1530. (Epub 12/10/19) (*-equal first authors, $-co-corresponding authors)

251. Y. Zhang,* Y. Sun,* Y. Shi, T. Walz$ & L. Tong.$ (2020). Structural insights into the human pre-mRNA 3'-end processing machinery. Mol. Cell, 77, 800-809. (Epub 12/3/19) (*-equal first authors, $-co-corresponding authors)

252. S.K. Doamekpor,* E. Grudzien-Nogalska,* A. Mlynarska-Cieslak, J. Kowalska, M. Kiledjian$ & L. Tong.$ (2020). DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs. Nucl. Acids Res. 48, 6136-6148. (*-equal first authors, $-co-corresponding authors)

253. S. Sharma, E. Grudzien-Nogalska,* K. Hamilton,* X. Jiao, J. Yang, L. Tong & M. Kiledjian. (2020). Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. Nucl. Acids Res. 48, 6788-6798. (*-equal second authors)

254. B.N. Peterson, M.K.M. Young, S. Luo, J. Wang, A.T. Whiteley, J.J. Woodward, L. Tong, J.D. Wang & D.A. Portnoy. (2020). (p)ppGpp and c-di-AMP homeostasis is controlled by CbpB in Listeria monocytogenes. mBio, 11, e01625-20.

255. X.-C. Yang,* Y. Sun,* W.S. Aik, W.F. Marzluff, L. Tong$ & Z. Dominski.$ (2020). Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5'-3' exonuclease. RNA, 26, 1345-1359. (*-equal first authors, $-co-corresponding authors)

256. K. Hamilton & L. Tong. (2020). Molecular mechanism for the interaction between human CPSF30 and hFip1. Genes Develop. 34, 1753-1761.

257. B. Ranjan, P.H. Choi, S. Pillai, K. Permaul, L. Tong$ & S. Singh.$ (2021). Crystal structure of a thermophilic fungal cyanase and its implications on the catalytic mechanism for bioremediation. Sci. Report, 11, 277. ($-co-corresponding authors)

258. S. Luo,* B.G. Coutinho,* P. Dadhwal,* Y. Oda, J. Ren, A.L. Shaefer, E.P. Greenberg,$ C.S. Harwood$ & L. Tong.$ (2021). Structural basis for a bacterial Pip system plant effector recognition protein. Proc. Natl. Acad. Sci. USA, 118, e2019462118. (*-equal first authors, $-co-corresponding authors)

259. C.M. Shan, J.K. Kim, J. Wang, K. Bao, Y. Sun, H. Chen, J.X. Yue, A. Stirpe, Z. Zhang, C. Lu, T. Schalch, G. Liti, P.L. Nagy, L. Tong, F. Qiao & S. Jia. (2021). The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin. Cell Reports, 35, 109137.

260. A.J. Pollock, P.H. Choi, S.A. Zaver, L. Tong & J.J. Woodward. (2021). A rationally designed c-di-AMP Forster resonance energy transfer biosensor to monitor nucleotide dynamics. J. Bacteriol. 203, e0008021.

261. P.A. Gutierrez, K. Baughman, Y. Sun & L. Tong. (2021). A real-time fluorescence assay for CPSF73, the nuclease for pre-mRNA 3'-end processing. RNA, 27, 1148-1154.

262. S. Sharma,* J. Yang,* S.K. Doamekpor, E. Grudzien-Nogalska, L. Tong & M. Kiledjian. (2022). Identification of a novel deFADding activity in human, yeast and bacterial 5' to 3' exoribonucleases. Nucl. Acids Res. 50, 8807-8817. (*-equal first authors)

263. M.-H. Lin,* M.K. Jensen,* N.D. Elrod, K.-L. Huang, K.A. Welle, E.J. Wagner$ & L. Tong.$ (2022). Inositol hexakisphosphate is required for Integrator function. Nature Commun. 13, 5742. (*-equal first authors, $-co-corresponding authors)

264. L.G. Mascibroda,* M. Shboul,* N.D. Elrod, L. Colleaux, H. Hamamy, K.-L. Huang, N. Peart, M.K. Singh, H. Lee, B. Merriman, J.N. Jodoin, P. Sitaram, L.A. Lee, R. Fathalla, B. Al-Rawashdeh, O. Ababneh, M. El-Khateeb, N. Escande-Beillard, S.F. Nelson, Y. Wu, L. Tong, L.J. Kenney, S. Roy, W.K. Russell, J. Amiel, B. Reversade$ & E.J. Wagner.$ (2022). INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex. Nature Commun. 13, 6054. (*-equal first authors, $-co-corresponding authors)

265. J.P. Lopez-Alonso, M. Lazaro, D. Gil-Carton, P.H. Choi, A. Dodu, L. Tong & M. Valle. (2022). CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase. Nature Commun. 13, 6185.

266. P.A. Gutierrez, J. Wei, Y. Sun & L. Tong. (2022). Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF. RNA, 28, 1534-1541.

267. C. Reglero, C.L. Dieck, A. Zask, F. Forouhar, A.P. Laurent, W.-H.W. Lin, R. Albero, H.I. Miller, C. Ma, J.M. Gastier-Foster, M.L. Loh, L. Tong, B.R. Stockwell, T. Palomero & A.A. Ferrando. (2022). Pharmacological inhibition of NT5C2 reverses genetic and nongenetic drivers of 6-MP resistance in acute lymphoblastic leukemia. Cancer Discovery, 12, 2646-2665.

268. J. Zhang, J. Huang, K. Xu, P. Xing, Y. Huang, Z. Liu, L. Tong & J.L. Manley. (2022). DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. Proc. Natl. Acad. Sci. USA, 119, e2216712119.

 

Reviews, book chapters, and invited papers

1. A. M. de Vos, L. Tong, M. V. Milburn, P. M. Matias & S.-H. Kim. (1988). Plenum Publishing Corporation, New York. Three-dimensional structure of ras p21 proteins. The guanine-nucleotide binding proteins: common structural and functional properties, Proceedings of an EMBO-NATO-CEC Advanced Research Workshop 165, 27-34.

2. S.-H. Kim, A. M. de Vos, L. Tong, M. V. Milburn, P. M. Matias, J. Jancarik & S. Nishimura. (1988). ras Oncogene proteins: Three-dimensional structures, functional implications, and a model for signal transducer. Cold Spring Harbor Symposia on Quantitative Biology, LIII, 273-281.

3. M. G. Rossmann, R. McKenna, L. Tong, D. Xia, J.-B. Dai, H. Wu, H.-K. Choi, D. Marinescu & R. E. Lynch. (1992). E. Dodson, S. Gover, and W. Wolf, eds. Science and Engineering Research Council, Daresbury. Molecular replacement real space averaging. Proc. of the CCP4 Study Weekend, 31 January - 1 February, 1992, 33-48.

4. L. Tong & M. G. Rossmann. (1997). Rotation function calculations with GLRF program. Methods in Enzymology, 276, 594-611.

5. H. Wu, Y. C. Park, H. Ye & L. Tong (1999). Structural studies of human TRAF-2. Cold Spring Harbor Symp. Quant. Biol. (Signaling and gene expression in the immune system). 64, 541-549.

6. Z. Yang & L. Tong. (2000). Structural studies of a human malic enzyme. Protein Peptide Lett. 7, 287-296.

7. L. Tong. (2001). Translation functions. Chapter 13.3 of International Tables for Crystallography, Vol. F. Crystallography of Biological Macromolecules. M. G. Rossmann & E. Arnold Eds. Kluwer Academic Publishers, The Netherlands.

8. L. Tong. (2001). How to take advantage of non-crystallographic symmetry in molecular replacement: The locked rotation and translation functions. Acta Cryst. D57, 1383-1389.

9. R. Batra, R. Khayat & L. Tong. (2001). Structural studies of herpesvirus proteases. Protein Peptide Lett. 8, 333-342.

10. L. Tong. (2002). Viral proteases. Chemical Reviews, 102, 4609-4626.

11. G.-G. Chang & L. Tong. (2003). Structure and function of malic enzymes, a new class of oxidative decarboxylases. Biochem. 42, 12721-12733.

12. G. Jogl, Y.-S. Hsiao & L. Tong. (2004). Structure and function of carnitine acyltransferases. Ann. N.Y. Acad. Sci. 1033, 17-29.

13. L. Tong. (2005). Toll/interleukin-1 receptors and innate immunity. in G. Waksman, M.G. Caparon & S. Hultgren, eds. Structural basis of bacterial pathogenesis. pp. 241-263. ASM Press, Washington, DC.

14. L. Tong. (2005). Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery. Cell. Mol. Life Sci. 62, 1784-1803.

15. L. Tong & H.J. Harwood Jr. (2006). Acetyl-coenzyme A carboxylases: versatile targets for drug discovery. J. Cell. Biochem. 99, 1476-1488

16. J.A. Khan, F. Forouhar, X. Tao & L. Tong. (2007). Nicotinamide adenine dinucleotide metabolism as attractive target for drug discovery. Expert Opin. Thera. Targets, 11, 695-705.

17. C.R. Mandel & L. Tong. (2007). How to get all "A"s in polyadenylation. Structure, 15, 1024-1026.

18. F. Forouhar, A. Kuzin, J. Seetharaman, I. Lee, W. Zhou, M. Abashidze, Y. Chen, W. Yong, H. Janjua, Y. Fang, D. Wang, K. Cunningham, R. Xiao, T.B. Acton, E. Pichersky, D.F. Klessig, C.W. Porter, G.T. Montelione, & L. Tong. (2007). Functional insights from structural genomics. J. Struct. Funct. Genomics, 8, 37-44.

19. D.F. Klessig, D. Kumar, F. Forouhar, L. Tong, Y. Yang, E. Pichersky, G.T. Montelione, Y. Chen, S.W. Park, A.C. Vlot & V. Shulaev. (2007). Salicylic acid-binding protein (SABP) 2 and systemic acquired resistance. In F. Sanchez, C. Quinto, I. M. Lopez-Lara & O. Geiger, eds. Biology of Plant-Microbe Interactions, 5, 176-181.

20. Structural Genomics Consortium, China Structural Genomics Consortium, Northeast Structural Genomics Consortium, S. Graslund, P. Nordlund, J. Weigelt, J. Bray, O. Gileadi, S. Knapp, U. Oppermann, C. Arrowsmith, R. Hui, J. Ming, S. dhe-Paganon, H.W. Park, A. Savchenko, A. Yee, A. Edwards, R. Vincentelli, C. Cambillau, R. Kim, S.H. Kim, Z. Rao, Y. Shi, T.C. Terwilliger, C.Y. Kim, L.W. Hung, G.S. Waldo, Y. Peleg, S. Albeck, T. Unger, O. Dym, J. Prilusky, J.L. Sussman, R.C. Stevens, S.A. Lesley, I.A. Wilson, A. Joachimiak, F. Collart, I. Dementieva, M.I. Donnelly, W.H. Eschenfeldt, Y. Kim, L. Stols, R. Wu, M. Zhou, S.K. Burley, J.S. Emtage, J.M. Sauder, D. Thompson, K. Bain, J. Luz, T. Gheyi, F. Zhang, S. Atwell, S.C. Almo, J.B. Bonanno, A. Fiser, S. Swaminathan, F.W. Studier, M.R. Chance, A. Sali, T.B. Acton, R. Xiao, L. Zhao, L.C. Ma, J.F. Hunt, L. Tong, K. Cunningham, M. Inouye, S. Anderson, H. Janjua, R. Shastry, C.K. Ho, D. Wang, H. Wang, M. Jiang, G.T. Montelione, D.I. Stuart, R.J. Owens, S. Daenke, A. Schutz, U. Heinemann, S. Yokoyama, K. Bussow & K.C. Gunsalus. (2008). Protein production and purification. Nature Methods, 5, 135-146.

21. C.R. Mandel, Y. Bai & L. Tong. (2008). Protein factors in pre-mRNA 3'-end processing. Cell. Mol. Life Sci. 65, 1099-1122.

22. L. Tong, E. Arnold & M.G. Rossmann. (2008). Patterson and molecular-replacement techniques. Chapter 2.3 of International Tables for Crystallography, Vol. B. U. Shmueli Ed. Kluwer Academic Publishers, The Netherlands.

23. S.J. Thackray, C. Bruckmann, C.G. Mowat, F. Forouhar, S.K. Chapman & L. Tong. (2008). Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase. Handbook of Metalloproteins. A. Messerschmidt, Ed., John Wiley & Sons, Chichester, UK.

24. X. Tao & L. Tong. (2009). Expression, purification and crystallization of Toll/Interleukin-1 Receptor (TIR) Domains. Methods Mol. Biol., Vol. 517, Chapter 6, pp. 81-88. C.E. McCoy & L.A.J. O'Neill, Eds. Humana Press.

25. J.H. Chang, S. Xiang & L. Tong. (2011). 5'-3' Exoribonucleases. A.W. Nicholson, Ed., Ribonucleases, Chapter 7, pp. 167-192, Nucleic Acids and Molecular Biology 26, Springer-Verlag Berlin Heidelberg.

26. L. Tong. (2012). Translation functions. Chapter 13.3 of International Tables for Crystallography, Vol. F. 2nd Ed. Crystallography of Biological Macromolecules. E. Arnold, D.M. Himmel & M.G. Rossmann, Eds. Wiley, Hoboken, NJ.

27. S.M. Vorobiev, Y.J. Huang, J. Seetharaman, R. Xiao, T.B. Acton, G.T. Montelione & L. Tong. (2012). Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers. Protein Peptide Lett. 19, 194-197.

28. J.H. Chang & L. Tong. (2012). Mitochondrial poly(A) polymerase and polyadenylation. Biochim. Biophys. Acta, 1819, 992-997.

29. J.H. Chang, S. Xiang & L. Tong. (2012). Structures of 5'-3' exoribonucleases (XRNs). G.F. Chanfreau & F. Tamanoi Eds. The Enzymes, Vol. 31. Eukaryotic RNases and their partners in RNA degradation and biogenesis, part A. Chapter 6, pp. 116-129. Academic Press.

30. S. Xiang, G. Usunow, G. Lange, M. Busch & L. Tong. (2013). 1-deoxy-D-xylulose 5-phosphate synthase (DXS), a crucial enzyme for isoprenoids biosynthesis. in Isoprenoid synthesis in plants and microorganisms: New concepts and experimental approaches, Chapter 2, pp. 17-28. T.J. Bach & M. Rohmer Eds. Springer, New York, Heidelberg, Dordrecht, London.

31. L. Tong. (2013). Structure and function of biotin-dependent carboxylases. Cell. Mol. Life Sci. 70, 863-891.

32. L.F. Cunha, L. Tong & J.D. Hsieh. (2013). Taspase1. Handbook of proteolytic enzymes, 3rd Ed. Volume 3, Chapter 822, pp. 3723-3728. N.D. Rawlings & G. Salvesen Eds. Elsevier.

33. A.R. Jurado, D. Tan, X. Jiao, M. Kiledjian & L. Tong. (2014). Structure and function of pre-mRNA 5'-end capping quality control and 3'-end processing.  Biochem. 53, 1882-1898.

34. K. Xiang, L. Tong & J.L. Manley. (2014). Delineating the structural blueprint of the pre-mRNA 3' end processing machinery. Mol. Cell. Biol. 34, 1894-1910.

35. J.K. Everett, R. Tejero, S.B.K. Murthy, T.B. Acton, J.M. Aramini, M.C. Baran, J. Benach, J.R. Cort, A. Eletsky, F. Forouhar, R. Guan, A.P. Kuzin, H.-W. Lee, G. Liu, R. Mani, B. Mao, J.L. Mills, A.F. Montelione, K. Pederson, R. Powers, T. Ramelot, P. Rossi, J. Seetharaman, D. Snyder, G.V.T. Swapna, S.M. Vorobiev, Y. Wu, R. Xiao, Y. Yang, C.H. Arrowsmith, J.F. Hunt, M.A. Kennedy, J.H. Prestegard, T. Szyperski, L. Tong & G.T. Montelione. (2016). A community resource of experimental data for NMR - X-ray crystal structure pairs. Protein Science, 25, 30-45.

36. Z. Liu, C. Gutierrez-Vargas, J. Wei, R.A. Grassucci, M. Sun, N. Espina, S. Madison-Antenucci, L. Tong & J. Frank. (2017). Determination of the ribosome structure to a resolution of 2.5 A by single-particle cryo-EM. Protein Science, 26, 82-92.

37. L. Tong. (2017). Striking diversity in holoenzyme architecture and extensive conformational variability in biotin-dependent carboxylases. Adv. Prot. Chem. Struct. Biol. Structural and Mechanistic Enzymology, 109, 161-194. Ed. T. Karabencheva-Christova. Elsevier, UK.

38. S. Luo & L. Tong. (2018). Structural biology of the separase-securin complex with crucial roles in chromosome segregation. Curr. Opin. Struct. Biol. 49, 114-122.

39. J. Wei & L. Tong. (2018). How does polymerization regulate human acetyl-CoA carboxylase 1? Biochem. 57, 5495-5496. (Viewpoint)

40. C. Xiao$ & L. Tong.$ (2019). Michael G. Rossmann (1930-2019). Structure, 27, 1347-1349. (Obituary) ($-co-corresponding authors)

41. L. Tong$ & J.J. Woodward.$ (2020). Metabolic regulation by cyclic di-AMP signaling. in Microbial Cyclic Di-Nucleotide Signaling, Chapter 10, pp. 161-175. S.-H. Chou, N. Guiliani, V. Lee & U. Romling Eds. Springer, New York, Heidelberg, Dordrecht, London. ($-co-corresponding authors)

42. Y. Sun, K. Hamilton & L. Tong. (2020). Recent molecular insights into canonical pre-mRNA 3'-end processing. Transcription, 11, 83-96.

43. J.H. Van Drie$ & L. Tong.$ (2020). Cryo-EM as a powerful tool for drug discovery. Bioorg. Med. Chem. Lett. 30, 127524. ($-co-corresponding authors)

44. S. Luo & L. Tong. (2020). Structure and function of the separase-securin complex. in Macromolecular Protein Complexes III: Structure and Function, Chapter 4, pp. 217-232. J.R. Harris & J. Marles-Wright Eds. Springer, New York, Heidelberg, Dordrecht, London. Alternatively Subcellular Biochem. 96, 217-232.

45. L. Tong. (2021). How to diSARM the executioner of axon degeneration. Nature Struct. Mol. Biol. 28, 10-12. (Epub 12/21/20, News & Views feature)

46. Y. Sun, W.S. Aik, X.-C. Yang, W.F. Marzluff, Z. Dominski$ & L. Tong.$ (2021). Reconstitution and biochemical assays of an active human histone pre-mRNA 3'-end processing machinery. Methods Enzymol. 655, 292-324. ($-co-corresponding authors)

47. Z. Dominski$ & L. Tong$ (2021). U7 deciphered: the mechanism that forms the unusual 3' end of metazoan replication-dependent histone mRNAs. Biochem. Soc. Trans. 49, 2229-2240. ($-co-corresponding authors)

48. S.K. Doamekpor,* S. Sharma,* M. Kiledjian$ & L. Tong.$ (2022). Recent insights into noncanonical 5' capping and decapping of RNA. J. Biol. Chem. 298, 102171. (*-equal first authors, $-co-corresponding authors)